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Differential cardiovascular and hypothalamic pituitary response to amphetamine in male pathological gamblers versus healthy controls.
Zack, Martin; Boileau, Isabelle; Payer, Doris; Chugani, Bindiya; Lobo, Daniela S; Houle, Sylvain; Wilson, Alan A; Warsh, Jerry J; Kish, Stephen J.
Afiliación
  • Zack M; Centre for Addiction and Mental Health, Toronto, ON, Canada martin.zack@camh.ca.
  • Boileau I; Centre for Addiction and Mental Health, Toronto, ON, Canada.
  • Payer D; Centre for Addiction and Mental Health, Toronto, ON, Canada.
  • Chugani B; Centre for Addiction and Mental Health, Toronto, ON, Canada.
  • Lobo DS; Centre for Addiction and Mental Health, Toronto, ON, Canada.
  • Houle S; Centre for Addiction and Mental Health, Toronto, ON, Canada.
  • Wilson AA; Centre for Addiction and Mental Health, Toronto, ON, Canada.
  • Warsh JJ; Centre for Addiction and Mental Health, Toronto, ON, Canada.
  • Kish SJ; Centre for Addiction and Mental Health, Toronto, ON, Canada.
J Psychopharmacol ; 29(9): 971-82, 2015 Sep.
Article en En | MEDLINE | ID: mdl-26152320
Cardiovascular and hypothalamic pituitary axis (HPA) disturbances have been observed in individuals who are pathological gamblers (PGs). These may partly derive from chronic exposure to gambling. Response to amphetamine (AMPH) may reveal such disturbances while controlling for differential conditioned responses to gambling in PGs vs healthy controls (HCs). This study assessed heart rate (HR), systolic blood pressure (SBP) and diastolic blood pressure (DBP) and plasma cortisol following oral AMPH (0.4 mg/kg) in male PGs (n=12) and HCs (n=11) who underwent a positron emission tomography (PET) scan. The Stop Signal Task enabled assessment of the link between physiological and behavioral dysregulation. Trait moderating effects were explored. The responses of PGs to AMPH differed from those of HCs on every index. PGs displayed persistent elevation in DBP and concomitant reduction in HR (i.e. baroreflex) compared to HCs beyond 90 min post-dose. PGs displayed deficits in cortisol compared to HCs that were partially reversed by AMPH. Impairment on the Stop Signal Task correlated positively with HR in controls, but negatively with HR in PGs, suggesting that strong initial and compensatory cardiac responses to a stimulant may each predict disinhibition. Extraversion predicted greater disinhibition in PGs. Noradrenergic disturbances may contribute to sensitized responses to stimulant challenge and disinhibition in PGs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hipófisis / Sistema Cardiovascular / Juego de Azar / Anfetamina / Estimulantes del Sistema Nervioso Central / Hipotálamo Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adult / Humans / Male Idioma: En Revista: J Psychopharmacol Asunto de la revista: PSICOFARMACOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hipófisis / Sistema Cardiovascular / Juego de Azar / Anfetamina / Estimulantes del Sistema Nervioso Central / Hipotálamo Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adult / Humans / Male Idioma: En Revista: J Psychopharmacol Asunto de la revista: PSICOFARMACOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos