Organogermanium compound, Ge-132, forms complexes with adrenaline, ATP and other physiological cis-diol compounds.
Future Med Chem
; 7(10): 1233-46, 2015.
Article
en En
| MEDLINE
| ID: mdl-26144262
BACKGROUND: In mammals, adrenaline and ATP are life-essential vicinal diol and cis-diol functional groups. Here, we show that interactions between a safe organogermanium compound and these cis-diol compounds have the potential to regulate physiological functions. In addition, we represent a possible new druggable target for controlling the action of cis-diol compounds. RESULTS: We analyzed a single crystal structure of organogermanium 3-(trihydroxygermyl)propanoic acid (THGPA), a hydrolysate of safe Ge-132, in complex with catecholamine (adrenaline and noradrenaline), and evaluated the affinity between several cis-diol compounds and THGPA by NMR. An in vitro study using normal human epidermal keratinocytes was performed to investigate the inhibition of cis-diol compound-stimulated receptors by THGPA. At high concentration, THGPA inhibited the calcium influx caused by adrenaline and ATP. CONCLUSION: This study demonstrates that THGPA can modify cis-diol-mediated cell-to-cell signaling.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Compuestos Organometálicos
/
Epinefrina
/
Adenosina Trifosfato
Límite:
Humans
Idioma:
En
Revista:
Future Med Chem
Año:
2015
Tipo del documento:
Article
País de afiliación:
Japón
Pais de publicación:
Reino Unido