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Endogenous ligands of natural killer T cells are alpha-linked glycosylceramides.
Kain, Lisa; Costanzo, Anne; Webb, Bill; Holt, Marie; Bendelac, Albert; Savage, Paul B; Teyton, Luc.
Afiliación
  • Kain L; The Scripps Research Institute, Department of Immunology and Microbial Science, La Jolla, CA 92037, USA.
  • Costanzo A; The Scripps Research Institute, Department of Immunology and Microbial Science, La Jolla, CA 92037, USA.
  • Webb B; Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Holt M; The Scripps Research Institute, Department of Immunology and Microbial Science, La Jolla, CA 92037, USA.
  • Bendelac A; University of Chicago, Committee on Immunology, Chicago, IL 60637, USA.
  • Savage PB; Brigham Young University, Department of Chemistry, Brigham Young University, Provo, UT 84602, USA.
  • Teyton L; The Scripps Research Institute, Department of Immunology and Microbial Science, La Jolla, CA 92037, USA. Electronic address: lteyton@scripps.edu.
Mol Immunol ; 68(2 Pt A): 94-7, 2015 Dec.
Article en En | MEDLINE | ID: mdl-26141240
The nature of the endogenous ligands for natural killer T (NKT) cells has been debated for more than a decade. Because the mammalian glycosylceramide synthases are invertases, it is believed that in mammals all glycosylceramides are ß anomers. However, the possibility that an alternative enzymatic pathway, an unfaithful enzyme, or unique physico-chemical environments could allow the production of small quantities of α anomers should be entertained. Classic biochemical and chemical analysis approaches are not well suited for this challenge as they lack sensitivity. Using a combination of biological assays and new technological approaches, we have unequivocally demonstrated that α glycosylceramides were constitutively produced by mammalian immune cells, loaded onto CD1d and presented to NKT cells both in the thymus and in the periphery. Their amount is controlled tightly by catabolic enzymes, and can be altered in vitro and in vivo to modify NKT cell behavior.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Asesinas Naturales / Ceramidas / Timocitos / Células Presentadoras de Antígenos Límite: Animals / Humans Idioma: En Revista: Mol Immunol Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Asesinas Naturales / Ceramidas / Timocitos / Células Presentadoras de Antígenos Límite: Animals / Humans Idioma: En Revista: Mol Immunol Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido