Regulation of Transcript Elongation.
Annu Rev Microbiol
; 69: 49-69, 2015.
Article
en En
| MEDLINE
| ID: mdl-26132790
Bacteria lack subcellular compartments and harbor a single RNA polymerase that synthesizes both structural and protein-coding RNAs, which are cotranscriptionally processed by distinct pathways. Nascent rRNAs fold into elaborate secondary structures and associate with ribosomal proteins, whereas nascent mRNAs are translated by ribosomes. During elongation, nucleic acid signals and regulatory proteins modulate concurrent RNA-processing events, instruct RNA polymerase where to pause and terminate transcription, or act as roadblocks to the moving enzyme. Communications among complexes that carry out transcription, translation, repair, and other cellular processes ensure timely execution of the gene expression program and survival under conditions of stress. This network is maintained by auxiliary proteins that act as bridges between RNA polymerase, ribosome, and repair enzymes, blurring boundaries between separate information-processing steps and making assignments of unique regulatory functions meaningless. Understanding the regulation of transcript elongation thus requires genome-wide approaches, which confirm known and reveal new regulatory connections.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Bacterias
/
ARN Polimerasas Dirigidas por ADN
/
Regulación Bacteriana de la Expresión Génica
/
Elongación de la Transcripción Genética
Idioma:
En
Revista:
Annu Rev Microbiol
Año:
2015
Tipo del documento:
Article
Pais de publicación:
Estados Unidos