Your browser doesn't support javascript.
loading
Polymorphisms of MMP9 and TIMP2 in Patients with Varicose Veins.
Kunt, Atike Tekeli; Isbir, Selim; Gormus, Uzay; Kahraman, Ozlem Timirci; Arsan, Sinan; Yilmaz, Seda Gulec; Isbir, Turgay.
Afiliación
  • Kunt AT; Department of Cardiovascular Surgery, Kocaeli Derince Education and Research Hospital, Kocaeli, Turkey.
  • Isbir S; Department of Cardiovascular Surgery, Faculty of Medicine, Marmara University, Istanbul, Turkey.
  • Gormus U; Department of Biochemistry, Faculty of Medicine, Istanbul Bilim University, Istanbul, Turkey.
  • Kahraman OT; Department of Molecular Medicine, Istanbul University Institute of Experimental Medicine, Istanbul, Turkey.
  • Arsan S; Department of Cardiovascular Surgery, Faculty of Medicine, Marmara University, Istanbul, Turkey.
  • Yilmaz SG; Department of Molecular Medicine, Institute of Health Sciences, Yeditepe University, Istanbul, Turkey.
  • Isbir T; Department of Medical Biology, Faculty of Medicine, Yeditepe University, Istanbul, Turkey tisbir@superonline.com.
In Vivo ; 29(4): 461-5, 2015.
Article en En | MEDLINE | ID: mdl-26130791
BACKGROUND: Genetic predisposition is a suggested risk factor in the etiology of varicose veins. The matrix metalloproteinase (MMP) family degrades extracellular matrix (ECM) and may lead to disturbances in vein wall structure. The activity of MMPs in the ECM are controlled by specific tissue inhibitors of MMPs (TIMP). The present study aimed to investigate the relationship between MMP9 and TIMP2 gene polymorphisms and varicose vein risk. MATERIALS AND METHODS: Genotyping of the polymorphisms of MMP9 (1562 C/T) and TIMP2 (418G/C) was performed using polymerase chain reaction and restriction-fragment length polymorphism assays in a group of patients with varicose veins (n=63) and healthy controls (n=70). RESULTS: The frequencies of MMP9 alleles and genotypes did not differ significantly between patient and control groups. However, TIMP2 -418 C allele was associated with increased risk for varicose vein formation (p=0.007). It was also shown that the frequency of the GG genotype was significantly higher in the control group than in the patient group (odds ratio=0.333, 95% confidence interval=0.14-0.78, p=0.012). CONCLUSION: TIMP2 -418 C allele is associated with susceptibility for varicose vein formation and individuals with GG genotype may have a lower risk for varicose vein formation.
Asunto(s)
Palabras clave
Buscar en Google
Añadir a Mi BVS
Imprimir
XML
PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polimorfismo Genético / Várices / Inhibidor Tisular de Metaloproteinasa-2 / Predisposición Genética a la Enfermedad / Metaloproteinasa 9 de la Matriz Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: In Vivo Asunto de la revista: NEOPLASIAS Año: 2015 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Grecia
Buscar en Google
Añadir a Mi BVS
Imprimir
XML
PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polimorfismo Genético / Várices / Inhibidor Tisular de Metaloproteinasa-2 / Predisposición Genética a la Enfermedad / Metaloproteinasa 9 de la Matriz Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: In Vivo Asunto de la revista: NEOPLASIAS Año: 2015 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Grecia