Your browser doesn't support javascript.
loading
Phenotypic and evolutionary implications of modulating the ERK-MAPK cascade using the dentition as a model.
Marangoni, Pauline; Charles, Cyril; Tafforeau, Paul; Laugel-Haushalter, Virginie; Joo, Adriane; Bloch-Zupan, Agnès; Klein, Ophir D; Viriot, Laurent.
Afiliación
  • Marangoni P; Evo-Devo of Vertebrate Dentition, Institute of Functional Genomics of Lyon, ENS de Lyon, CNRS UMR 5242, Université Lyon 1 - Université de Lyon, 46 allée d'Italie, 69364 Lyon cedex 07, France.
  • Charles C; Evo-Devo of Vertebrate Dentition, Institute of Functional Genomics of Lyon, ENS de Lyon, CNRS UMR 5242, Université Lyon 1 - Université de Lyon, 46 allée d'Italie, 69364 Lyon cedex 07, France.
  • Tafforeau P; European Synchrotron Radiation Facility, 71 avenue des Martyrs, CS-40220 F-38043 Grenoble cedex 09, France.
  • Laugel-Haushalter V; Development and Stem Cells Department, Institute of Genetics and Molecular and Cellular Biology, Inserm U 964, CNRS UMR 7104, Université de Strasbourg, BP 10142, 67404 Illkirch, France.
  • Joo A; Department of Orofacial Sciences and Program in Craniofacial Biology, University of California, San Francisco, CA 94143-0442, USA.
  • Bloch-Zupan A; 1] Development and Stem Cells Department, Institute of Genetics and Molecular and Cellular Biology, Inserm U 964, CNRS UMR 7104, Université de Strasbourg, BP 10142, 67404 Illkirch, France [2] Faculty of Dentistry, University of Strasbourg, 8 rue St Elisabeth, 67000 Strasbourg, France [3] Reference C
  • Klein OD; 1] Department of Orofacial Sciences and Program in Craniofacial Biology, University of California, San Francisco, CA 94143-0442, USA [2] Department of Pediatrics and Institute for Human Genetics, University of California San Francisco, San Francisco, CA 94143, USA.
  • Viriot L; Evo-Devo of Vertebrate Dentition, Institute of Functional Genomics of Lyon, ENS de Lyon, CNRS UMR 5242, Université Lyon 1 - Université de Lyon, 46 allée d'Italie, 69364 Lyon cedex 07, France.
Sci Rep ; 5: 11658, 2015 Jun 30.
Article en En | MEDLINE | ID: mdl-26123406
The question of phenotypic convergence across a signalling pathway has important implications for both developmental and evolutionary biology. The ERK-MAPK cascade is known to play a central role in dental development, but the relative roles of its components remain unknown. Here we investigate the diversity of dental phenotypes in Spry2(-/-), Spry4(-/-), and Rsk2(-/Y) mice, including the incidence of extra teeth, which were lost in the mouse lineage 45 million years ago (Ma). In addition, Sprouty-specific anomalies mimic a phenotype that is absent in extant mice but present in mouse ancestors prior to 9 Ma. Although the mutant lines studied display convergent phenotypes, each gene has a specific role in tooth number determination and crown patterning. The similarities found between teeth in fossils and mutants highlight the pivotal role of the ERK-MAPK cascade during the evolution of the dentition in rodents.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistema de Señalización de MAP Quinasas / Quinasas MAP Reguladas por Señal Extracelular Límite: Animals Idioma: En Revista: Sci Rep Año: 2015 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistema de Señalización de MAP Quinasas / Quinasas MAP Reguladas por Señal Extracelular Límite: Animals Idioma: En Revista: Sci Rep Año: 2015 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido