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Prognostic role of copeptin after stroke: A systematic review and meta-analysis of observational studies.
Choi, Kyu-Sun; Kim, Hyun Jung; Chun, Hyoung-Joon; Kim, Jae Min; Yi, Hyeong-Joong; Cheong, Jin-Hwan; Kim, Choong-Hyun; Oh, Suck-Jun; Ko, Yong; Kim, Young-Soo; Bak, Koang-Hum; Ryu, Je-Il; Kim, Wonhee; Lim, Taeho; Ahn, Hyeong Sik; Ahn, Il Min; Lee, Seon-Heui.
Afiliación
  • Choi KS; Department of Neurosurgery, College of Medicine, Hanyang University, Seoul, Korea.
  • Kim HJ; Department of Preventive Medicine, College of Medicine, Korea University, Seoul, Korea.
  • Chun HJ; Department of Neurosurgery, College of Medicine, Hanyang University, Seoul, Korea.
  • Kim JM; Department of Neurosurgery, College of Medicine, Hanyang University, Seoul, Korea.
  • Yi HJ; Department of Neurosurgery, College of Medicine, Hanyang University, Seoul, Korea.
  • Cheong JH; Department of Neurosurgery, College of Medicine, Hanyang University, Seoul, Korea.
  • Kim CH; Department of Neurosurgery, College of Medicine, Hanyang University, Seoul, Korea.
  • Oh SJ; Department of Neurosurgery, College of Medicine, Hanyang University, Seoul, Korea.
  • Ko Y; Department of Neurosurgery, College of Medicine, Hanyang University, Seoul, Korea.
  • Kim YS; Department of Neurosurgery, College of Medicine, Hanyang University, Seoul, Korea.
  • Bak KH; Department of Neurosurgery, College of Medicine, Hanyang University, Seoul, Korea.
  • Ryu JI; Department of Neurosurgery, College of Medicine, Hanyang University, Seoul, Korea.
  • Kim W; Department of Emergency Medicine, College of Medicine, Hallym University, Seoul, Korea.
  • Lim T; Department of Emergency Medicine, College of Medicine, Hanyang University, Seoul, Korea.
  • Ahn HS; Department of Preventive Medicine, College of Medicine, Korea University, Seoul, Korea.
  • Ahn IM; 1] Department of Preventive Medicine, College of Medicine, Korea University, Seoul, Korea [2] Department of Literary Arts, Brown University, Rhode Island, USA.
  • Lee SH; Department of Nursing Science, College of Nursing, Gachon University, Incheon, Korea.
Sci Rep ; 5: 11665, 2015 Jun 29.
Article en En | MEDLINE | ID: mdl-26119473
Copeptin, the C-terminal part of provasopressin, has emerged as a novel prognostic marker after hemorrhagic or ischemic stroke. The aim of this study was to quantitatively assess the prognostic significance of plasma copeptin level on functional outcome and mortality in patients with acute stroke using a meta-analysis of the available evidence. Thirteen relevant studies from 2,746 patients were finally included in our study. An elevated plasma copeptin level was associated with an increased risk of unfavorable outcome and mortality after stroke (OR 1.77; 95% CI, 1.44-2.19 and OR 3.90; 95% CI 3.07-4.95, respectively). The result of the pooled measure on standardized mean difference (SMD) was that plasma copeptin levels were found to be significantly higher in patients who died compared to survivors (SMD 1.70; 95% CI, 1.36-2.03). A stratified analysis by study region showed significant differences in SMD of copeptin, and the heterogeneity among studies was significantly decreased. However, the positive association of copeptin with poor prognosis after stroke was consistent in each stratified analysis. The present meta-analysis suggests that early measurement of plasma copeptin could provide better prognostic information about functional outcome and mortality in patients with acute stroke.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glicopéptidos / Accidente Cerebrovascular / Estudios Observacionales como Asunto Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Sci Rep Año: 2015 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glicopéptidos / Accidente Cerebrovascular / Estudios Observacionales como Asunto Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Sci Rep Año: 2015 Tipo del documento: Article Pais de publicación: Reino Unido