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Cidea improves the metabolic profile through expansion of adipose tissue.
Abreu-Vieira, Gustavo; Fischer, Alexander W; Mattsson, Charlotte; de Jong, Jasper M A; Shabalina, Irina G; Rydén, Mikael; Laurencikiene, Jurga; Arner, Peter; Cannon, Barbara; Nedergaard, Jan; Petrovic, Natasa.
Afiliación
  • Abreu-Vieira G; Department of Molecular Biosciences, Wenner-Gren Institute, Arrhenius Laboratories F3, Stockholm University, 106 91 Stockholm, Sweden.
  • Fischer AW; 1] Department of Molecular Biosciences, Wenner-Gren Institute, Arrhenius Laboratories F3, Stockholm University, 106 91 Stockholm, Sweden [2] Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
  • Mattsson C; Department of Cell and Molecular Biology, Karolinska Institutet, 171 77 Stockholm, Sweden.
  • de Jong JM; Department of Molecular Biosciences, Wenner-Gren Institute, Arrhenius Laboratories F3, Stockholm University, 106 91 Stockholm, Sweden.
  • Shabalina IG; Department of Molecular Biosciences, Wenner-Gren Institute, Arrhenius Laboratories F3, Stockholm University, 106 91 Stockholm, Sweden.
  • Rydén M; Department of Medicine, Huddinge, Lipid Laboratory, Karolinska Institutet, 141 86 Stockholm, Sweden.
  • Laurencikiene J; Department of Medicine, Huddinge, Lipid Laboratory, Karolinska Institutet, 141 86 Stockholm, Sweden.
  • Arner P; Department of Medicine, Huddinge, Lipid Laboratory, Karolinska Institutet, 141 86 Stockholm, Sweden.
  • Cannon B; Department of Molecular Biosciences, Wenner-Gren Institute, Arrhenius Laboratories F3, Stockholm University, 106 91 Stockholm, Sweden.
  • Nedergaard J; Department of Molecular Biosciences, Wenner-Gren Institute, Arrhenius Laboratories F3, Stockholm University, 106 91 Stockholm, Sweden.
  • Petrovic N; Department of Molecular Biosciences, Wenner-Gren Institute, Arrhenius Laboratories F3, Stockholm University, 106 91 Stockholm, Sweden.
Nat Commun ; 6: 7433, 2015 Jun 29.
Article en En | MEDLINE | ID: mdl-26118629
In humans, Cidea (cell death-inducing DNA fragmentation factor alpha-like effector A) is highly but variably expressed in white fat, and expression correlates with metabolic health. Here we generate transgenic mice expressing human Cidea in adipose tissues (aP2-hCidea mice) and show that Cidea is mechanistically associated with a robust increase in adipose tissue expandability. Under humanized conditions (thermoneutrality, mature age and prolonged exposure to high-fat diet), aP2-hCidea mice develop a much more pronounced obesity than their wild-type littermates. Remarkably, the malfunctioning of visceral fat normally caused by massive obesity is fully overcome-perilipin 1 and Akt expression are preserved, tissue degradation is prevented, macrophage accumulation is decreased and adiponectin expression remains high. Importantly, the aP2-hCidea mice display enhanced insulin sensitivity. Our data establish a functional role for Cidea and suggest that, in humans, the association between Cidea levels in white fat and metabolic health is not only correlative but also causative.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tejido Adiposo / Metabolismo Energético / Proteínas Reguladoras de la Apoptosis Límite: Animals Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2015 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Reino Unido
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tejido Adiposo / Metabolismo Energético / Proteínas Reguladoras de la Apoptosis Límite: Animals Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2015 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Reino Unido