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Cortical sources of resting state electroencephalographic rhythms differ in relapsing-remitting and secondary progressive multiple sclerosis.
Babiloni, Claudio; Del Percio, Claudio; Capotosto, Paolo; Noce, Giuseppe; Infarinato, Francesco; Muratori, Chiara; Marcotulli, Christian; Bellagamba, Giovanni; Righi, Elena; Soricelli, Andrea; Onorati, Paolo; Lupattelli, Tommaso.
Afiliación
  • Babiloni C; Department of Physiology and Pharmacology, University of Rome "La Sapienza", Rome, Italy; IRCCS San Raffaele Pisana, Rome, Italy. Electronic address: claudio.babiloni@uniroma1.it.
  • Del Percio C; IRCCS San Raffaele Pisana, Rome, Italy.
  • Capotosto P; Department of Neuroscience and Imaging and Clinical Science, and ITAB, University "G. D'Annunzio", Chieti, Italy.
  • Noce G; IRCCS S.D.N., Naples, Italy.
  • Infarinato F; IRCCS San Raffaele Pisana, Rome, Italy.
  • Muratori C; Istituto Clinico Cardiologico (ICC), Casalpalocco, Rome, Italy.
  • Marcotulli C; Department of Sciences and Medical-Surgical Biotechnology, University of Rome "La Sapienza", Rome, Italy.
  • Bellagamba G; Istituto Clinico Cardiologico (ICC), Casalpalocco, Rome, Italy.
  • Righi E; Istituto Clinico Cardiologico (ICC), Casalpalocco, Rome, Italy.
  • Soricelli A; IRCCS S.D.N., Naples, Italy; Department of Studies of Institutions and Territorial Systems, University of Naples "Parthenope", Naples, Italy.
  • Onorati P; Department of Physiology and Pharmacology, University of Rome "La Sapienza", Rome, Italy; Istituto Clinico Cardiologico (ICC), Casalpalocco, Rome, Italy.
  • Lupattelli T; Istituto Clinico Cardiologico (ICC), Casalpalocco, Rome, Italy.
Clin Neurophysiol ; 127(1): 581-590, 2016 Jan.
Article en En | MEDLINE | ID: mdl-26111485
OBJECTIVE: Resting state electroencephalographic (EEG) rhythms are abnormal in multiple sclerosis (MS) patients, but it is unclear if they can reflect different neurophysiologic abnormalities in MS sub-types (phenotypes) such as relapsing-remitting (RR) and secondary progressive (SP). METHODS: We tested whether cortical sources of resting state EEG rhythms are abnormal in MS patients and differ between MS phenotypes. Resting state eyes-closed EEG activity was recorded in 36 RR, 23 SP, and 41 matched healthy subjects. EEG bands of interest were individually identified based on Transition frequency (TF), Individual alpha frequency (IAF), and Individual beta frequency (IBF). LORETA freeware estimated cortical EEG sources. RESULTS: Widespread TF -4Hz (delta) and IAF (alpha) cortical sources were abnormal in the MS sub-groups compared to the control group. Furthermore, TF -4Hz sources in central, parietal, and limbic regions were higher in amplitude in the SP compared to the RR sub-group. CONCLUSION: Cortical sources of resting state EEG rhythms are abnormal in MS patients at group level and differ between RR and SP sub-groups. SIGNIFICANCE: Future studies should test the utility of these EEG markers in the diagnosis and management of MS clinical phenotypes and in the therapy evaluation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Descanso / Corteza Cerebral / Esclerosis Múltiple Crónica Progresiva / Esclerosis Múltiple Recurrente-Remitente / Electroencefalografía Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Neurophysiol Asunto de la revista: NEUROLOGIA / PSICOFISIOLOGIA Año: 2016 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Descanso / Corteza Cerebral / Esclerosis Múltiple Crónica Progresiva / Esclerosis Múltiple Recurrente-Remitente / Electroencefalografía Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Neurophysiol Asunto de la revista: NEUROLOGIA / PSICOFISIOLOGIA Año: 2016 Tipo del documento: Article Pais de publicación: Países Bajos