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DNA Methylation Levels of Melanoma Risk Genes Are Associated with Clinical Characteristics of Melanoma Patients.
de Araújo, Érica S S; Pramio, Dimitrius T; Kashiwabara, André Y; Pennacchi, Paula C; Maria-Engler, Silvya S; Achatz, Maria I; Campos, Antonio H J F M; Duprat, João P; Rosenberg, Carla; Carraro, Dirce M; Krepischi, Ana C V.
Afiliación
  • de Araújo ÉS; International Research Center, A.C.Camargo Cancer Center, Rua Taguá 440, 01508010 São Paulo, SP, Brazil.
  • Pramio DT; International Research Center, A.C.Camargo Cancer Center, Rua Taguá 440, 01508010 São Paulo, SP, Brazil.
  • Kashiwabara AY; Federal Technological University of Paraná, Avenida Alberto Carazzai 1640, 86300000 Cornélio Procópio, PR, Brazil.
  • Pennacchi PC; School of Pharmaceutical Sciences, University of São Paulo, Avenida Professor Lineu Prestes 580, 05508000 São Paulo, SP, Brazil.
  • Maria-Engler SS; School of Pharmaceutical Sciences, University of São Paulo, Avenida Professor Lineu Prestes 580, 05508000 São Paulo, SP, Brazil.
  • Achatz MI; International Research Center, A.C.Camargo Cancer Center, Rua Taguá 440, 01508010 São Paulo, SP, Brazil ; Department of Oncogenetics, A.C.Camargo Cancer Center, Rua Professor Antônio Prudente 211, 01509010 São Paulo, SP, Brazil.
  • Campos AH; Department of Pathology, A.C.Camargo Cancer Center, Rua Professor Antônio Prudente 211, 01509010 São Paulo, SP, Brazil.
  • Duprat JP; Skin Cancer Department, A.C.Camargo Cancer Center, Rua Professor Antônio Prudente 211, 01509010 São Paulo, SP, Brazil.
  • Rosenberg C; Department of Genetics and Evolutionary Biology, Institute of Biosciences, University of São Paulo, Rua do Matão 277, 05508090 São Paulo, SP, Brazil.
  • Carraro DM; International Research Center, A.C.Camargo Cancer Center, Rua Taguá 440, 01508010 São Paulo, SP, Brazil.
  • Krepischi AC; International Research Center, A.C.Camargo Cancer Center, Rua Taguá 440, 01508010 São Paulo, SP, Brazil ; Department of Genetics and Evolutionary Biology, Institute of Biosciences, University of São Paulo, Rua do Matão 277, 05508090 São Paulo, SP, Brazil.
Biomed Res Int ; 2015: 376423, 2015.
Article en En | MEDLINE | ID: mdl-26106605
In melanoma development, oncogenic process is mediated by genetic and epigenetic mutations, and few studies have so far explored the role of DNA methylation either as predisposition factor or biomarker. We tested patient samples for germline CDKN2A methylation status and found no evidence of inactivation by promoter hypermethylation. We have also investigated the association of clinical characteristics of samples with the DNA methylation pattern of twelve genes relevant for melanomagenesis. Five genes (BAP1, MGMT, MITF, PALB2, and POT1) presented statistical association between blood DNA methylation levels and either CDKN2A-mutation status, number of lesions, or Breslow thickness. In tumors, five genes (KIT, MGMT, MITF, TERT, and TNF) exhibited methylation levels significantly different between tumor groups including acral compared to nonacral melanomas and matched primary lesions and metastases. Our data pinpoint that the methylation level of eight melanoma-associated genes could potentially represent markers for this disease both in peripheral blood and in tumor samples.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Metilación de ADN / Epigénesis Genética / Melanoma Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Female / Humans / Male Idioma: En Revista: Biomed Res Int Año: 2015 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Metilación de ADN / Epigénesis Genética / Melanoma Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Female / Humans / Male Idioma: En Revista: Biomed Res Int Año: 2015 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos