Your browser doesn't support javascript.
loading
Postinfarction Functional Recovery Driven by a Three-Dimensional Engineered Fibrin Patch Composed of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells.
Roura, Santiago; Soler-Botija, Carolina; Bagó, Juli R; Llucià-Valldeperas, Aida; Férnandez, Marco A; Gálvez-Montón, Carolina; Prat-Vidal, Cristina; Perea-Gil, Isaac; Blanco, Jerónimo; Bayes-Genis, Antoni.
Afiliación
  • Roura S; Heart Failure and Cardiac Regeneration Research Program and Flow Cytometry Facility, Germans Trias i Pujol Health Science Research Institute, Badalona, Spain; Cell Therapy Group, Institute for Advanced Chemistry of Catalonia, Barcelona, Spain; Biomedical Research Networking Center on Bioengineering,
  • Soler-Botija C; Heart Failure and Cardiac Regeneration Research Program and Flow Cytometry Facility, Germans Trias i Pujol Health Science Research Institute, Badalona, Spain; Cell Therapy Group, Institute for Advanced Chemistry of Catalonia, Barcelona, Spain; Biomedical Research Networking Center on Bioengineering,
  • Bagó JR; Heart Failure and Cardiac Regeneration Research Program and Flow Cytometry Facility, Germans Trias i Pujol Health Science Research Institute, Badalona, Spain; Cell Therapy Group, Institute for Advanced Chemistry of Catalonia, Barcelona, Spain; Biomedical Research Networking Center on Bioengineering,
  • Llucià-Valldeperas A; Heart Failure and Cardiac Regeneration Research Program and Flow Cytometry Facility, Germans Trias i Pujol Health Science Research Institute, Badalona, Spain; Cell Therapy Group, Institute for Advanced Chemistry of Catalonia, Barcelona, Spain; Biomedical Research Networking Center on Bioengineering,
  • Férnandez MA; Heart Failure and Cardiac Regeneration Research Program and Flow Cytometry Facility, Germans Trias i Pujol Health Science Research Institute, Badalona, Spain; Cell Therapy Group, Institute for Advanced Chemistry of Catalonia, Barcelona, Spain; Biomedical Research Networking Center on Bioengineering,
  • Gálvez-Montón C; Heart Failure and Cardiac Regeneration Research Program and Flow Cytometry Facility, Germans Trias i Pujol Health Science Research Institute, Badalona, Spain; Cell Therapy Group, Institute for Advanced Chemistry of Catalonia, Barcelona, Spain; Biomedical Research Networking Center on Bioengineering,
  • Prat-Vidal C; Heart Failure and Cardiac Regeneration Research Program and Flow Cytometry Facility, Germans Trias i Pujol Health Science Research Institute, Badalona, Spain; Cell Therapy Group, Institute for Advanced Chemistry of Catalonia, Barcelona, Spain; Biomedical Research Networking Center on Bioengineering,
  • Perea-Gil I; Heart Failure and Cardiac Regeneration Research Program and Flow Cytometry Facility, Germans Trias i Pujol Health Science Research Institute, Badalona, Spain; Cell Therapy Group, Institute for Advanced Chemistry of Catalonia, Barcelona, Spain; Biomedical Research Networking Center on Bioengineering,
  • Blanco J; Heart Failure and Cardiac Regeneration Research Program and Flow Cytometry Facility, Germans Trias i Pujol Health Science Research Institute, Badalona, Spain; Cell Therapy Group, Institute for Advanced Chemistry of Catalonia, Barcelona, Spain; Biomedical Research Networking Center on Bioengineering,
  • Bayes-Genis A; Heart Failure and Cardiac Regeneration Research Program and Flow Cytometry Facility, Germans Trias i Pujol Health Science Research Institute, Badalona, Spain; Cell Therapy Group, Institute for Advanced Chemistry of Catalonia, Barcelona, Spain; Biomedical Research Networking Center on Bioengineering,
Stem Cells Transl Med ; 4(8): 956-66, 2015 Aug.
Article en En | MEDLINE | ID: mdl-26106218
Considerable research has been dedicated to restoring myocardial cell slippage and limiting ventricular remodeling after myocardial infarction (MI). We examined the ability of a three-dimensional (3D) engineered fibrin patch filled with human umbilical cord blood-derived mesenchymal stem cells (UCBMSCs) to induce recovery of cardiac function after MI. The UCBMSCs were modified to coexpress luciferase and fluorescent protein reporters, mixed with fibrin, and applied as an adhesive, viable construct (fibrin-cell patch) over the infarcted myocardium in mice (MI-UCBMSC group). The patch adhered well to the heart. Noninvasive bioluminescence imaging demonstrated early proliferation and differentiation of UCBMSCs within the construct in the postinfarct mice in the MI-UCBMSC group. The implanted cells also participated in the formation of new, functional microvasculature that connected the fibrin-cell patch to both the subjacent myocardial tissue and the host circulatory system. As revealed by echocardiography, the left ventricular ejection fraction and fractional shortening at sacrifice were improved in MI-UCBMSC mice and were markedly reduced in mice treated with fibrin alone and untreated postinfarction controls. In conclusion, a 3D engineered fibrin patch composed of UCBMSCs attenuated infarct-derived cardiac dysfunction when transplanted locally over a myocardial wound.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fibrina / Trasplante de Células Madre Mesenquimatosas / Células Madre Mesenquimatosas / Infarto del Miocardio Límite: Animals / Humans Idioma: En Revista: Stem Cells Transl Med Año: 2015 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fibrina / Trasplante de Células Madre Mesenquimatosas / Células Madre Mesenquimatosas / Infarto del Miocardio Límite: Animals / Humans Idioma: En Revista: Stem Cells Transl Med Año: 2015 Tipo del documento: Article Pais de publicación: Reino Unido