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Cumulative Small Effect Genetic Markers and the Risk of Colorectal Cancer in Poland, Estonia, Lithuania, and Latvia.
Serrano-Fernandez, Pablo; Dymerska, Dagmara; Kurzawski, Grzegorz; Derkacz, Róza; Sobieszczanska, Tatiana; Banaszkiewicz, Zbigniew; Roomere, Hanno; Oitmaa, Eneli; Metspalu, Andres; Janavicius, Ramunas; Elsakov, Pavel; Razumas, Mindaugas; Petrulis, Kestutis; Irmejs, Arvids; Miklasevics, Edvins; Scott, Rodney J; Lubinski, Jan.
Afiliación
  • Serrano-Fernandez P; Hereditary Cancer Center, Department of genetics and Pathology, Pomeranian Medical University, Ulica Polabska 4, 70-115 Szczecin, Poland.
  • Dymerska D; Hereditary Cancer Center, Department of genetics and Pathology, Pomeranian Medical University, Ulica Polabska 4, 70-115 Szczecin, Poland.
  • Kurzawski G; Hereditary Cancer Center, Department of genetics and Pathology, Pomeranian Medical University, Ulica Polabska 4, 70-115 Szczecin, Poland.
  • Derkacz R; Hereditary Cancer Center, Department of genetics and Pathology, Pomeranian Medical University, Ulica Polabska 4, 70-115 Szczecin, Poland.
  • Sobieszczanska T; Hereditary Cancer Center, Department of genetics and Pathology, Pomeranian Medical University, Ulica Polabska 4, 70-115 Szczecin, Poland.
  • Banaszkiewicz Z; Department of Surgery, Collegium Medicum, Nicolaus Copernicus University, Ulica Jagiellonska 13-15, 85-067 Bydgoszcz, Poland.
  • Roomere H; Asper Biotech, Vaksali 17a, 50410 Tartu, Estonia.
  • Oitmaa E; Asper Biotech, Vaksali 17a, 50410 Tartu, Estonia.
  • Metspalu A; The Estonian Academy of Sciences, Kohtu 6, 10130 Tallinn, Estonia ; Institute of Molecular and Cell Biology, University of Tartu, Riia 23, 23b-134, 51010 Tartu, Estonia ; Estonian Genome Centre of University of Tartu, Riia 23, 23b-134, 51010 Tartu, Estonia.
  • Janavicius R; Department of Molecular and Regenerative Medicine, Hematology, Oncology and Transfusion Medicine Center, Vilnius University Hospital Santariskiu Clinics, Santariskiu g. 2, LT-08661 Vilnius, Lithuania ; State Research Institute, Innovative Medicine Center, Zygimantu 9, LT-01102 Vilnius, Lithuania.
  • Elsakov P; State Research Institute, Innovative Medicine Center, Zygimantu 9, LT-01102 Vilnius, Lithuania.
  • Razumas M; Vilnius Maternity Hospital, Santariskiu g. 2, LT-08661 Vilnius, Lithuania.
  • Petrulis K; Institute of Oncology, Vilnius University, 21/27 M. K. Ciurlionio, LT-03101 Vilnius, Lithuania.
  • Irmejs A; Hereditary Cancer Center, Stradins University, Dzirciema 16 (Pardaugava), Riga LV-1007, Latvia ; Pauls Stradins Clinical University Hospital, Pilsonu 13, Riga LV-1002, Latvia.
  • Miklasevics E; Hereditary Cancer Center, Stradins University, Dzirciema 16 (Pardaugava), Riga LV-1007, Latvia ; Pauls Stradins Clinical University Hospital, Pilsonu 13, Riga LV-1002, Latvia.
  • Scott RJ; Hereditary Cancer Center, Department of genetics and Pathology, Pomeranian Medical University, Ulica Polabska 4, 70-115 Szczecin, Poland ; Discipline of Medical Genetics, Faculty of Health, University of Newcastle and the Hunter Medical Research Institute, University Drive, Callaghan, NSW 2308, Aust
  • Lubinski J; Hereditary Cancer Center, Department of genetics and Pathology, Pomeranian Medical University, Ulica Polabska 4, 70-115 Szczecin, Poland.
Gastroenterol Res Pract ; 2015: 204089, 2015.
Article en En | MEDLINE | ID: mdl-26101521
The continued identification of new low-penetrance genetic variants for colorectal cancer (CRC) raises the question of their potential cumulative effect among compound carriers. We focused on 6 SNPs (rs380284, rs4464148, rs4779584, rs4939827, rs6983267, and rs10795668), already described as risk markers, and tested their possible independent and combined contribution to CRC predisposition. Material and Methods. DNA was collected and genotyped from 2330 unselected consecutive CRC cases and controls from Estonia (166 cases and controls), Latvia (81 cases and controls), Lithuania (123 cases and controls), and Poland (795 cases and controls). Results. Beyond individual effects, the analysis revealed statistically significant linear cumulative effects for these 6 markers for all samples except of the Latvian one (corrected P value = 0.018 for the Estonian, corrected P value = 0.0034 for the Lithuanian, and corrected P value = 0.0076 for the Polish sample). Conclusions. The significant linear cumulative effects demonstrated here support the idea of using sets of low-risk markers for delimiting new groups with high-risk of CRC in clinical practice that are not carriers of the usual CRC high-risk markers.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Etiology_studies / Risk_factors_studies Idioma: En Revista: Gastroenterol Res Pract Año: 2015 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Egipto
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Etiology_studies / Risk_factors_studies Idioma: En Revista: Gastroenterol Res Pract Año: 2015 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Egipto