Bf and C4 phenotypes in patients with psoriasis.

Wyatt, R J; Wang, C; Hudson, E C; Jones, R M; Noah, P W; Rosenberg, E W

Wyatt, R J; Wang, C; Hudson, E C; Jones, R M; Noah, P W; Rosenberg, E W.

Afiliación

Wyatt RJ; Department of Pediatrics, University of Tennessee, Memphis.

Acta Derm Venereol Suppl (Stockh) ; 146: 211-3, 1989.

Article en En | MEDLINE | ID: mdl-2609873

RESUMEN

Phenotype frequencies for the complement proteins Bf (factor B), C4A and C4B were performed in a sample of 49 Caucasian patients with psoriasis followed in Memphis, Tennessee. The genes for these proteins are located in the major histocompatibility complex between the HLA-B and HLA-DR loci. Bf phenotype frequency did not differ significantly for the patients as compared to regional controls. The C4*A6 allele was present in 26.6% of the patients as compared to 5.4% of the controls, p less than 0.001, relative risk = 4.93. The C4*A6 allele is known to be in linkage disequilibrium with the HLA B17 allele and produces a functionally defective gene product. The role, if any, of C4*A6 in the pathogenesis of psoriasis is uncertain.

Asunto(s)

Complemento C4/genética; Factor B del Complemento/genética; Precursores Enzimáticos/genética; Psoriasis/genética; Electroforesis/métodos; Humanos; Fenotipo

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Psoriasis / Complemento C4 / Factor B del Complemento / Precursores Enzimáticos Tipo de estudio: Etiology_studies Límite: Humans Idioma: En Revista: Acta Derm Venereol Suppl (Stockh) Año: 1989 Tipo del documento: Article Pais de publicación: Noruega

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