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An Adaptive Thresholding Method for BTV Estimation Incorporating PET Reconstruction Parameters: A Multicenter Study of the Robustness and the Reliability.
Brambilla, M; Matheoud, R; Basile, C; Bracco, C; Castiglioni, I; Cavedon, C; Cremonesi, M; Morzenti, S; Fioroni, F; Giri, M; Botta, F; Gallivanone, F; Grassi, E; Pacilio, M; De Ponti, E; Stasi, M; Pasetto, S; Valzano, S; Zanni, D.
Afiliación
  • Brambilla M; Department of Medical Physics, University Hospital Maggiore della Carità, 28100 Novara, Italy.
  • Matheoud R; Department of Medical Physics, University Hospital Maggiore della Carità, 28100 Novara, Italy.
  • Basile C; Department of Medical Physics, Hospital S. Camillo Forlanini, 00152 Roma, Italy.
  • Bracco C; Department of Medical Physics, Institute for Cancer Research and Treatment (IRCC), 10060 Candiolo, Italy.
  • Castiglioni I; Institute of Molecular Bioimaging and Physiology, National Research Council (IBFM-CNR), 20093 Milan, Italy.
  • Cavedon C; Department of Medical Physics, University Hospital, 37126 Verona, Italy.
  • Cremonesi M; Department of Nuclear Medicine, European Institute of Oncology, 20141 Milan, Italy.
  • Morzenti S; Department of Medical Physics, Hospital San Gerardo, 20900 Monza, Italy.
  • Fioroni F; Department of Medical Physics, Arcispedale S.Maria Nuova, IRCCS, 42123 Reggio Emilia, Italy.
  • Giri M; Department of Medical Physics, University Hospital, 37126 Verona, Italy.
  • Botta F; Department of Nuclear Medicine, European Institute of Oncology, 20141 Milan, Italy.
  • Gallivanone F; Institute of Molecular Bioimaging and Physiology, National Research Council (IBFM-CNR), 20093 Milan, Italy.
  • Grassi E; Department of Medical Physics, Arcispedale S.Maria Nuova, IRCCS, 42123 Reggio Emilia, Italy.
  • Pacilio M; Department of Medical Physics, Hospital S. Camillo Forlanini, 00152 Roma, Italy.
  • De Ponti E; Department of Medical Physics, Hospital San Gerardo, 20900 Monza, Italy.
  • Stasi M; Department of Medical Physics, Institute for Cancer Research and Treatment (IRCC), 10060 Candiolo, Italy.
  • Pasetto S; Department of Medical Physics, Hospital Niguarda, 20162 Milan, Italy.
  • Valzano S; Department of Medical Physics, University Hospital Maggiore della Carità, 28100 Novara, Italy.
  • Zanni D; Department of Medical Physics, Hospital Niguarda, 20162 Milan, Italy.
Comput Math Methods Med ; 2015: 571473, 2015.
Article en En | MEDLINE | ID: mdl-26078777
OBJECTIVE: The aim of this work was to assess robustness and reliability of an adaptive thresholding algorithm for the biological target volume estimation incorporating reconstruction parameters. METHOD: In a multicenter study, a phantom with spheres of different diameters (6.5-57.4 mm) was filled with (18)F-FDG at different target-to-background ratios (TBR: 2.5-70) and scanned for different acquisition periods (2-5 min). Image reconstruction algorithms were used varying number of iterations and postreconstruction transaxial smoothing. Optimal thresholds (TS) for volume estimation were determined as percentage of the maximum intensity in the cross section area of the spheres. Multiple regression techniques were used to identify relevant predictors of TS. RESULTS: The goodness of the model fit was high (R(2): 0.74-0.92). TBR was the most significant predictor of TS. For all scanners, except the Gemini scanners, FWHM was an independent predictor of TS. Significant differences were observed between scanners of different models, but not between different scanners of the same model. The shrinkage on cross validation was small and indicative of excellent reliability of model estimation. CONCLUSIONS: Incorporation of postreconstruction filtering FWHM in an adaptive thresholding algorithm for the BTV estimation allows obtaining a robust and reliable method to be applied to a variety of different scanners, without scanner-specific individual calibration.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tomografía de Emisión de Positrones Tipo de estudio: Clinical_trials / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Comput Math Methods Med Asunto de la revista: INFORMATICA MEDICA Año: 2015 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tomografía de Emisión de Positrones Tipo de estudio: Clinical_trials / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Comput Math Methods Med Asunto de la revista: INFORMATICA MEDICA Año: 2015 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos