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Decreased gray matter volume in inferior frontal gyrus is related to stop-signal task performance in alcohol-dependent patients.
Wiers, Corinde E; Gawron, Christiane K; Gröpper, Sonja; Spengler, Stephanie; Stuke, Heiner; Lindenmeyer, Johannes; Walter, Henrik; Bermpohl, Felix.
Afiliación
  • Wiers CE; Department of Psychiatry and Psychotherapy Charité-Universitätsmedizin Berlin, Charité Campus Mitte, Germany; Berlin School of Mind and Brain, Humboldt-Universität zu Berlin, Germany. Electronic address: corinde.wiers@nih.gov.
  • Gawron CK; Department of Psychiatry and Psychotherapy Charité-Universitätsmedizin Berlin, Charité Campus Mitte, Germany.
  • Gröpper S; Department of Psychiatry and Psychotherapy Charité-Universitätsmedizin Berlin, Charité Campus Mitte, Germany.
  • Spengler S; Department of Psychiatry and Psychotherapy Charité-Universitätsmedizin Berlin, Charité Campus Mitte, Germany.
  • Stuke H; Department of Psychiatry and Psychotherapy Charité-Universitätsmedizin Berlin, Charité Campus Mitte, Germany.
  • Lindenmeyer J; Salus Klinik, Lindow, Germany.
  • Walter H; Department of Psychiatry and Psychotherapy Charité-Universitätsmedizin Berlin, Charité Campus Mitte, Germany; Berlin School of Mind and Brain, Humboldt-Universität zu Berlin, Germany.
  • Bermpohl F; Department of Psychiatry and Psychotherapy Charité-Universitätsmedizin Berlin, Charité Campus Mitte, Germany; Berlin School of Mind and Brain, Humboldt-Universität zu Berlin, Germany.
Psychiatry Res ; 233(2): 125-30, 2015 Aug 30.
Article en En | MEDLINE | ID: mdl-26078198
Impairment in inhibitory control has been proposed to contribute to habitual alcohol use, abuse and eventually dependence. Moreover, alcohol-dependent (AD) patients have shown a loss of gray matter volume (GMV) in the brain, specifically in prefrontal regions associated with executive functions, including response inhibition. To date, no study has evaluated whether this prefrontal GMV reduction is related to response inhibition in alcohol dependence. To address this issue, we acquired high-resolution T1-weighted magnetic resonance mages from recently detoxified AD patients (n = 22) and healthy controls (HC; n = 21). Differences in local GMV between groups were assessed by means of voxel-based morphometry (VBM). Moreover, within the AD group, mean local GMV reductions were extracted and correlated with behavioral performance on the stop-signal task. We found a significantly decrease in GMV in the left inferior frontal gyrus (IFG) in AD patients compared with HC subjects. Further, mean local GMV in this area correlated positively with reaction times on go trials during the stop-signal task in AD patients. Our findings suggest that GMV losses in the IFG in AD patients are related to faster go responses on the stop-signal task.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Desempeño Psicomotor / Corteza Prefrontal / Alcoholismo / Función Ejecutiva / Inhibición Psicológica Límite: Adult / Humans / Male / Middle aged Idioma: En Revista: Psychiatry Res Año: 2015 Tipo del documento: Article Pais de publicación: Irlanda
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Desempeño Psicomotor / Corteza Prefrontal / Alcoholismo / Función Ejecutiva / Inhibición Psicológica Límite: Adult / Humans / Male / Middle aged Idioma: En Revista: Psychiatry Res Año: 2015 Tipo del documento: Article Pais de publicación: Irlanda