Anti-influenza activities of polyphenols from the medicinal mushroom Phellinus baumii.

Hwang, Byung Soon; Lee, In-Kyoung; Choi, Hwa Jung; Yun, Bong-Sik

Hwang, Byung Soon; Lee, In-Kyoung; Choi, Hwa Jung; Yun, Bong-Sik.

Afiliación

Hwang BS; Division of Biotechnology and Advanced Institute of Environment and Bioscience, Chonbuk National University, 79 Gobong-ro, Iksan-si 570-752, Republic of Korea.
Lee IK; Division of Biotechnology and Advanced Institute of Environment and Bioscience, Chonbuk National University, 79 Gobong-ro, Iksan-si 570-752, Republic of Korea.
Choi HJ; Department of Beauty Science, Kwangju Women's University, 165 Sanjeong-dong, Gwangsan-gu, Kwangju 506-713, Republic of Korea.
Yun BS; Division of Biotechnology and Advanced Institute of Environment and Bioscience, Chonbuk National University, 79 Gobong-ro, Iksan-si 570-752, Republic of Korea. Electronic address: bsyun@jbnu.ac.kr.

Bioorg Med Chem Lett ; 25(16): 3256-60, 2015 Aug 15.

Article en En | MEDLINE | ID: mdl-26077494

RESUMEN

Five polyphenols were isolated from the ethanolic extract of the fruiting bodies of Phellinus baumii. These compounds were identified by various spectroscopic methods as hispidin, hypholomine B, inoscavin A, davallialactone, and phelligridin D. All compounds inhibited noncompetitively H1N1, H5N1, and H3N2 neuraminidase activity and reduced the amount of virally-induced cytopathic effect (CPE) according to an MDCK cell-based assay.

Asunto(s)

Agaricales/química; Antivirales/farmacología; Basidiomycota/química; Orthomyxoviridae/efectos de los fármacos; Polifenoles/farmacología; Animales; Antivirales/aislamiento & purificación; Efecto Citopatogénico Viral/efectos de los fármacos; Perros; Relación Dosis-Respuesta a Droga; Cuerpos Fructíferos de los Hongos/química; Subtipo H1N1 del Virus de la Influenza A/efectos de los fármacos; Subtipo H1N1 del Virus de la Influenza A/enzimología; Subtipo H3N2 del Virus de la Influenza A/efectos de los fármacos; Subtipo H3N2 del Virus de la Influenza A/enzimología; Subtipo H5N1 del Virus de la Influenza A/efectos de los fármacos; Subtipo H5N1 del Virus de la Influenza A/enzimología; Cinética; Células de Riñón Canino Madin Darby; Medicina Tradicional de Asia Oriental; Neuraminidasa/antagonistas & inhibidores; Orthomyxoviridae/enzimología; Polifenoles/química; Polifenoles/aislamiento & purificación

Palabras clave

Anti-influenza; Cytopathic effect; Neuraminidase inhibition; Phellinus baumii; Polyphenol

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antivirales / Orthomyxoviridae / Basidiomycota / Agaricales / Polifenoles Límite: Animals Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2015 Tipo del documento: Article Pais de publicación: Reino Unido

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