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Neural substrates of negativity bias in women with and without major depression.
Gollan, Jackie K; Connolly, Megan; Buchanan, Angel; Hoxha, Denada; Rosebrock, Laina; Cacioppo, John; Csernansky, John; Wang, Xue.
Afiliación
  • Gollan JK; Northwestern University Feinberg School of Medicine, Department of Psychiatry and Behavioral Sciences, USA. Electronic address: j-gollan@northwestern.edu.
  • Connolly M; Northwestern University Feinberg School of Medicine, Department of Psychiatry and Behavioral Sciences, USA.
  • Buchanan A; Northwestern University Feinberg School of Medicine, Department of Psychiatry and Behavioral Sciences, USA.
  • Hoxha D; Northwestern University Feinberg School of Medicine, Department of Psychiatry and Behavioral Sciences, USA.
  • Rosebrock L; Northwestern University Feinberg School of Medicine, Department of Psychiatry and Behavioral Sciences, USA.
  • Cacioppo J; The University of Chicago, Center for Social Neuroscience, Department of Psychology, USA.
  • Csernansky J; Northwestern University Feinberg School of Medicine, Department of Psychiatry and Behavioral Sciences, USA.
  • Wang X; Northwestern University Feinberg School of Medicine, Department of Radiology, USA.
Biol Psychol ; 109: 184-91, 2015 Jul.
Article en En | MEDLINE | ID: mdl-26073417
BACKGROUND: The functional localization of negativity bias, an influential index of emotion information processing, has yet to be identified. METHOD: Depressed (n=47) and healthy participants (n=58) completed a clinical interview for DSM-IV Axis I disorders, symptom checklists, a behavioral task to measure negativity bias, and then viewed positive and negative images of social and nonsocial scenes during an event-related fMRI task. Two subsamples of participants with high (i.e., 75%; n=26) and low (i.e., 25%; n=26) negativity bias scores were as included in subsequent analyses to examine neural differences. RESULTS: Depressed participants with a higher, relative to lower, negative bias showed significantly greater neural activation in the left inferior frontal gyrus. CONCLUSION: High negativity bias evokes a distinctive pattern of brain activation in the frontal cortex of depressed participants. Increased activation occurred in the left inferior frontal gyrus, related to Brodmann area 44, which is associated with language and semantic processing, response inhibition, and cognitive reappraisal. This finding may reflect an abnormality in integrative emotional processing rather than processing of individual emotional dimensions in depressed participants with negativity bias.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Mapeo Encefálico / Corteza Prefrontal / Afecto / Trastorno Depresivo Mayor Tipo de estudio: Prognostic_studies Límite: Adolescent / Adult / Female / Humans / Middle aged Idioma: En Revista: Biol Psychol Año: 2015 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Mapeo Encefálico / Corteza Prefrontal / Afecto / Trastorno Depresivo Mayor Tipo de estudio: Prognostic_studies Límite: Adolescent / Adult / Female / Humans / Middle aged Idioma: En Revista: Biol Psychol Año: 2015 Tipo del documento: Article Pais de publicación: Países Bajos