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The Relationship Between Medial Temporal Lobe Atrophy and Cognitive Impairment in Patients With Dementia With Lewy Bodies.
Tagawa, Ryo; Hashimoto, Hiroshi; Nakanishi, Aki; Kawarada, Youjirou; Muramatsu, Tomohiro; Matsuda, Yasunori; Kataoka, Kouhei; Shimada, Aiko; Uchida, Kentaro; Yoshida, Atsushi; Higashiyama, Shigeaki; Kawabe, Joji; Kai, Toshihiro; Shiomi, Susumu; Mori, Hiroshi; Inoue, Koki.
Afiliación
  • Tagawa R; Department of Neuropsychiatry, Graduate School of Medicine, Osaka City University, Osaka, Japan m2032247@med.osaka-cu.ac.jp.
  • Hashimoto H; Department of Neuropsychiatry, Graduate School of Medicine, Osaka City University, Osaka, Japan.
  • Nakanishi A; Department of Neurology and Psychiatry, Osaka City Kousaiin Hospital, Osaka, Japan.
  • Kawarada Y; Department of Neurology and Psychiatry, Osaka City Kousaiin Hospital, Osaka, Japan.
  • Muramatsu T; Department of Neurology and Psychiatry, Osaka City Kousaiin Hospital, Osaka, Japan.
  • Matsuda Y; Department of Neuropsychiatry, Graduate School of Medicine, Osaka City University, Osaka, Japan.
  • Kataoka K; Department of Psychiatry, Cocoroa Hospital, Osaka, Japan.
  • Shimada A; Department of Neuropsychiatry, Graduate School of Medicine, Osaka City University, Osaka, Japan.
  • Uchida K; Department of Neuropsychiatry, Graduate School of Medicine, Osaka City University, Osaka, Japan.
  • Yoshida A; Department of Nuclear Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan.
  • Higashiyama S; Department of Nuclear Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan.
  • Kawabe J; Department of Nuclear Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan.
  • Kai T; Department of Psychiatry, Osaka City General Hospital, Osaka, Japan.
  • Shiomi S; Department of Nuclear Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan.
  • Mori H; Department of Neuroscience, Graduate School of Medicine, Osaka City University, Osaka, Japan.
  • Inoue K; Department of Neuropsychiatry, Graduate School of Medicine, Osaka City University, Osaka, Japan.
J Geriatr Psychiatry Neurol ; 28(4): 249-54, 2015 Dec.
Article en En | MEDLINE | ID: mdl-26071442
BACKGROUND: The relationship between medial temporal lobe atrophy (MTA) and cognitive impairment in patients with dementia with Lewy bodies (DLB) remains unclear. We examined this relationship using voxel-based specific regional analysis system for Alzheimer disease (VSRAD) advance software, which allowed us to quantify the degree of MTA on images obtained from magnetic resonance imaging (MRI) scans. METHODS: Thirty-seven patients diagnosed with DLB were recruited and scanned with a 1.5 Tesla MRI scanner. All MRI data were analyzed using VSRAD advance. The target volume of interest (VOI) included the entire region of the entorhinal cortex, hippocampus, and amygdala. The degree of MTA was obtained from the averaged positive z-score (Z score) on the target VOI, with higher scores indicating more severe MTA. Mini-Mental State Examination (MMSE) and the Revised Hasegawa Dementia Scale (HDS-R), which strengthened the measures of memory and language more than MMSE, were used to assess the presence of cognitive impairment. RESULTS: A negative correlation was found between the Z score and MMSE total scores or the HDS-R total scores. A stepwise multiple regression analysis performed to adjust the covariate effects of sex, age, the onset age of the disease, duration of DLB, years of education, and donepezil treatment showed that the HDS-R total scores were independently associated with the Z score, whereas MMSE total scores were not. CONCLUSIONS: These results suggest that MTA is related to cognitive impairment in patients with DLB, particularly the regions of orientation, immediate and delayed recall, and word fluency.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lóbulo Temporal / Trastornos del Conocimiento / Enfermedad por Cuerpos de Lewy Tipo de estudio: Diagnostic_studies Límite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: J Geriatr Psychiatry Neurol Asunto de la revista: GERIATRIA / NEUROLOGIA / PSIQUIATRIA Año: 2015 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lóbulo Temporal / Trastornos del Conocimiento / Enfermedad por Cuerpos de Lewy Tipo de estudio: Diagnostic_studies Límite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: J Geriatr Psychiatry Neurol Asunto de la revista: GERIATRIA / NEUROLOGIA / PSIQUIATRIA Año: 2015 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos