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Undetectable serum calcidiol: not everything that glitters is gold.
Gallegos-Bayas, Gioconda; Pascual-Pareja, José Francisco; Sanchez-Niño, Maria D; Manzarbeitia, Felix; Ortiz, Alberto.
Afiliación
  • Gallegos-Bayas G; Department of Family and Community Medicine, Centro de Salud Barrio del Pilar, Area 5, Madrid, Spain.
  • Pascual-Pareja JF; Department of Internal Medicine, Hospital Cantoblanco-La Paz, Universidad Autonoma de Madrid, Madrid, (IdiPAZ), Spain.
  • Sanchez-Niño MD; Department of Nephrology, IIS-Fundacion Jimenez Diaz, Universidad Autonoma de Madrid, Madrid, Spain.
  • Manzarbeitia F; Department of Pathology, IIS-Fundacion Jimenez Diaz, Universidad Autonoma de Madrid, Madrid, Spain.
  • Ortiz A; Department of Nephrology, IIS-Fundacion Jimenez Diaz, Universidad Autonoma de Madrid, Madrid, Spain.
Clin Kidney J ; 5(1): 37-40, 2012 Feb.
Article en En | MEDLINE | ID: mdl-26069745
There is an increased awareness of the adverse consequences of nutritional vitamin D deficiency. We report a patient with chronic tophaceous gout, chronic kidney disease (CKD) Stage 3/4 and undetectable serum calcidiol who developed severe hypercalcaemia upon vitamin D supplementation despite serum 25(OH) vitamin D within the normal range. Upon recovery, serum 1,25(OH)2 vitamin D remained in the normal range despite CKD and serum 25(OH) vitamin D 6 ng/mL. Gout tophi biopsies from additional patients showed macrophage expression of 25(OH) vitamin D 1α-hydroxylase. This case illustrates the dangers of supplementing vitamin D in patients with low serum 25(OH) vitamin D and increased 1α-hydroxylase activity due to granulomatous disease.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Clin Kidney J Año: 2012 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Clin Kidney J Año: 2012 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido