Goldberg Active Template Synthesis of a [2]Rotaxane Ligand for Asymmetric Transition-Metal Catalysis.

Hoekman, Steven; Kitching, Matthew O; Leigh, David A; Papmeyer, Marcus; Roke, Diederik

Hoekman, Steven; Kitching, Matthew O; Leigh, David A; Papmeyer, Marcus; Roke, Diederik.

Afiliación

Hoekman S; School of Chemistry, University of Manchester, Oxford Road, Manchester, M13 9PL, United Kingdom.
Kitching MO; School of Chemistry, University of Manchester, Oxford Road, Manchester, M13 9PL, United Kingdom.
Leigh DA; School of Chemistry, University of Manchester, Oxford Road, Manchester, M13 9PL, United Kingdom.
Papmeyer M; School of Chemistry, University of Manchester, Oxford Road, Manchester, M13 9PL, United Kingdom.
Roke D; School of Chemistry, University of Manchester, Oxford Road, Manchester, M13 9PL, United Kingdom.

J Am Chem Soc ; 137(24): 7656-9, 2015 Jun 24.

Article en En | MEDLINE | ID: mdl-26061430

RESUMEN

We report on the active template synthesis of a [2]rotaxane through a Goldberg copper-catalyzed C-N bond forming reaction. A C2-symmetric cyclohexyldiamine macrocycle directs the assembly of the rotaxane, which can subsequently serve as a ligand for enantioselective nickel-catalyzed conjugate addition reactions. Rotaxanes are a previously unexplored ligand architecture for asymmetric catalysis. We find that the rotaxane gives improved enantioselectivity compared to a noninterlocked ligand, at the expense of longer reaction times.

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Am Chem Soc Año: 2015 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google