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Associations of serum ß-carotene and retinol concentrations with insulin resistance: the Toon Health Study.
Higuchi, Kana; Saito, Isao; Maruyama, Koutatsu; Eguchi, Eri; Mori, Hiromi; Tanno, Sakurako; Sakurai, Susumu; Kishida, Taro; Nishida, Wataru; Osawa, Haruhiko; Tanigawa, Takeshi.
Afiliación
  • Higuchi K; Department of Basic Nursing and Health Science, Ehime University Graduate School of Medicine, Toon, Japan; Department of Diabetes and Molecular Genetics, Ehime University Graduate School of Medicine, Toon, Japan.
  • Saito I; Department of Basic Nursing and Health Science, Ehime University Graduate School of Medicine, Toon, Japan. Electronic address: saitoi@m.ehime-u.ac.jp.
  • Maruyama K; Department of Basic Medical Research and Education, Ehime University Graduate School of Medicine, Toon, Japan.
  • Eguchi E; Department of Public Health, Ehime University Graduate School of Medicine, Toon, Japan; Department of Public Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
  • Mori H; Department of Public Health, Ehime University Graduate School of Medicine, Toon, Japan.
  • Tanno S; Center for Sleep Medicine, Ehime University Hospital, Toon, Japan.
  • Sakurai S; Department of Clinical Laboratory Science, Faculty of Health Care, Tenri Health Care University, Tenri, Japan.
  • Kishida T; Faculty of Agriculture, Ehime University, Matsuyama, Japan.
  • Nishida W; Department of Diabetes and Molecular Genetics, Ehime University Graduate School of Medicine, Toon, Japan; Nishida Wataru Diabetes Clinic, Matsuyama, Japan.
  • Osawa H; Department of Diabetes and Molecular Genetics, Ehime University Graduate School of Medicine, Toon, Japan.
  • Tanigawa T; Department of Public Health, Juntendo University Graduate School of Medicine, Bunkyo, Japan.
Nutrition ; 31(7-8): 975-80, 2015.
Article en En | MEDLINE | ID: mdl-26059371
OBJECTIVE: Although green and yellow vegetables have beneficial effects against type 2 diabetes, the relationship of their nutritive content with insulin resistance is poorly understood. The aim of this study was to examine the associations of serum ß-carotene and retinol concentrations with glucose and insulin concentrations. METHODS: We recruited 951 Japanese men and women ages 30 to 79 y who were not undergoing treatment for diabetes and measured their serum ß-carotene and retinol concentrations. A 75-g oral glucose tolerance test was performed and the homeostasis model assessment for insulin resistance (HOMA-IR) and the Matsuda Index were calculated as measures of insulin resistance. Several confounding factors were adjusted for with multivariable logistic models. RESULTS: Multivariable-adjusted odds ratios of the highest quartile of serum ß-carotene compared with the lowest quartile for HOMA-IR >1.6 and Matsuda Index <4.9 were 0.56 (95% confidence interval, 0.34-0.94) and 0.62 (0.37-1.02), respectively. When stratified by sex and overweight status, these associations were observed for women and non-overweight individuals. Serum retinol concentration was not associated with either index. Furthermore, according to the nutritional survey, serum ß-carotene concentration was associated with green and yellow vegetable intake (P = 0.01). CONCLUSION: Our findings suggest that higher serum ß-carotene levels, associated with higher intake of green and yellow vegetables, confer beneficial effects against insulin resistance.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Verduras / Vitamina A / Resistencia a la Insulina / Beta Caroteno / Homeostasis Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Nutrition Asunto de la revista: CIENCIAS DA NUTRICAO Año: 2015 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Verduras / Vitamina A / Resistencia a la Insulina / Beta Caroteno / Homeostasis Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Nutrition Asunto de la revista: CIENCIAS DA NUTRICAO Año: 2015 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos