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AS1411-conjugated gold nanospheres and their potential for breast cancer therapy.
Malik, Mohammad T; O'Toole, Martin G; Casson, Lavona K; Thomas, Shelia D; Bardi, Gina T; Reyes-Reyes, Elsa Merit; Ng, Chin K; Kang, Kyung A; Bates, Paula J.
Afiliación
  • Malik MT; Departments of Medicine, University of Louisville, Louisville, Kentucky, USA.
  • O'Toole MG; Departments of the Molecular Targets Group of the James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky, USA.
  • Casson LK; Departments of Bioengineering, University of Louisville, Louisville, Kentucky, USA.
  • Thomas SD; Departments of Medicine, University of Louisville, Louisville, Kentucky, USA.
  • Bardi GT; Departments of the Molecular Targets Group of the James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky, USA.
  • Reyes-Reyes EM; Departments of Medicine, University of Louisville, Louisville, Kentucky, USA.
  • Ng CK; Departments of the Molecular Targets Group of the James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky, USA.
  • Kang KA; Departments of Medicine, University of Louisville, Louisville, Kentucky, USA.
  • Bates PJ; Departments of the Molecular Targets Group of the James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky, USA.
Oncotarget ; 6(26): 22270-81, 2015 Sep 08.
Article en En | MEDLINE | ID: mdl-26045302
AS1411 is a quadruplex-forming DNA oligonucleotide that functions as an aptamer to target nucleolin, a protein present on the surface of cancer cells. Clinical trials of AS1411 have indicated it is well tolerated with evidence of therapeutic activity, but improved pharmacology and potency may be required for optimal efficacy. In this report, we describe how conjugating AS1411 to 5 nm gold nanospheres influences its activities in vitro and in vivo. We find that the AS1411-linked gold nanospheres (AS1411-GNS) are stable in aqueous and serum-containing solutions. Compared to unconjugated AS1411 or GNS linked to control oligonucleotides, AS1411-GNS have superior cellular uptake and markedly increased antiproliferative/cytotoxic effects. Similar to AS1411, AS1411-GNS show selectivity for cancer cells compared to non-malignant cells. In a mouse model of breast cancer, systemic administration of AS1411-GNS could completely inhibit tumor growth with no signs of toxicity. These results suggest AS1411-GNS are promising candidates for clinical translation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oligodesoxirribonucleótidos / Neoplasias de la Mama / Nanopartículas del Metal / Nanosferas / Oro Tipo de estudio: Clinical_trials Límite: Animals / Female / Humans Idioma: En Revista: Oncotarget Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oligodesoxirribonucleótidos / Neoplasias de la Mama / Nanopartículas del Metal / Nanosferas / Oro Tipo de estudio: Clinical_trials Límite: Animals / Female / Humans Idioma: En Revista: Oncotarget Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos