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Serous cystic neoplasm of the pancreas: a multinational study of 2622 patients under the auspices of the International Association of Pancreatology and European Pancreatic Club (European Study Group on Cystic Tumors of the Pancreas).
Jais, B; Rebours, V; Malleo, G; Salvia, R; Fontana, M; Maggino, L; Bassi, C; Manfredi, R; Moran, R; Lennon, A M; Zaheer, A; Wolfgang, C; Hruban, R; Marchegiani, G; Fernández Del Castillo, C; Brugge, W; Ha, Y; Kim, M H; Oh, D; Hirai, I; Kimura, W; Jang, J Y; Kim, S W; Jung, W; Kang, H; Song, S Y; Kang, C M; Lee, W J; Crippa, S; Falconi, M; Gomatos, I; Neoptolemos, J; Milanetto, A C; Sperti, C; Ricci, C; Casadei, R; Bissolati, M; Balzano, G; Frigerio, I; Girelli, R; Delhaye, M; Bernier, B; Wang, H; Jang, K T; Song, D H; Huggett, M T; Oppong, K W; Pererva, L; Kopchak, K V; Del Chiaro, M.
Afiliación
  • Jais B; Department of Gastroenterology and Pancreatology, Beaujon Hospital, AP-HP, Clichy, France.
  • Rebours V; Department of Gastroenterology and Pancreatology, Beaujon Hospital, AP-HP, Clichy, France.
  • Malleo G; The Pancreas Institute, G.B. Rossi Hospital, University of Verona Hospital Trust, Verona, Italy.
  • Salvia R; The Pancreas Institute, G.B. Rossi Hospital, University of Verona Hospital Trust, Verona, Italy.
  • Fontana M; The Pancreas Institute, G.B. Rossi Hospital, University of Verona Hospital Trust, Verona, Italy.
  • Maggino L; The Pancreas Institute, G.B. Rossi Hospital, University of Verona Hospital Trust, Verona, Italy.
  • Bassi C; The Pancreas Institute, G.B. Rossi Hospital, University of Verona Hospital Trust, Verona, Italy.
  • Manfredi R; The Pancreas Institute, G.B. Rossi Hospital, University of Verona Hospital Trust, Verona, Italy.
  • Moran R; Division of Gastroenterology and Hepatology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA Division of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns
  • Lennon AM; Division of Gastroenterology and Hepatology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA Division of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns
  • Zaheer A; Division of Gastroenterology and Hepatology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA Division of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns
  • Wolfgang C; Division of Gastroenterology and Hepatology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA Division of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns
  • Hruban R; Division of Gastroenterology and Hepatology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA Division of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns
  • Marchegiani G; Departments of Surgery and Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Fernández Del Castillo C; Departments of Surgery and Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Brugge W; Departments of Surgery and Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Ha Y; Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
  • Kim MH; Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
  • Oh D; Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
  • Hirai I; First Department of Surgery, Yamagata University Faculty of Medicine, Yamagata, Japan.
  • Kimura W; First Department of Surgery, Yamagata University Faculty of Medicine, Yamagata, Japan.
  • Jang JY; Department of Surgery, Seoul National University College of Medicine, Seoul, Korea.
  • Kim SW; Department of Surgery, Seoul National University College of Medicine, Seoul, Korea.
  • Jung W; Department of Surgery, Seoul National University College of Medicine, Seoul, Korea.
  • Kang H; Division of Gastroenterology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
  • Song SY; Division of Gastroenterology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
  • Kang CM; Department of Surgery, Yonsei University College of Medicine, Pancreaticobiliary Cancer Clinic, Yonsei Cancer Center, Severance Hospital, Seoul, Korea.
  • Lee WJ; Department of Surgery, Yonsei University College of Medicine, Pancreaticobiliary Cancer Clinic, Yonsei Cancer Center, Severance Hospital, Seoul, Korea.
  • Crippa S; Pancreatic Surgery Unit, Department of Surgery, Polytechnic University of Marche Region, Ancona-Torrette, Italy.
  • Falconi M; Pancreatic Surgery Unit, Department of Surgery, Polytechnic University of Marche Region, Ancona-Torrette, Italy.
  • Gomatos I; NIHR Pancreas Biomedical Research Unit, Department of Molecular and Clinical Cancer Medicine, Royal Liverpool University Hospital, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.
  • Neoptolemos J; NIHR Pancreas Biomedical Research Unit, Department of Molecular and Clinical Cancer Medicine, Royal Liverpool University Hospital, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.
  • Milanetto AC; Department of Surgery, Oncology and Gastroenterology, 3rd Surgical Clinic, University of Padua, Padua, Italy.
  • Sperti C; Department of Surgery, Oncology and Gastroenterology, 3rd Surgical Clinic, University of Padua, Padua, Italy.
  • Ricci C; Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum-University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy.
  • Casadei R; Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum-University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy.
  • Bissolati M; Pancreatic Surgery Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Balzano G; Pancreatic Surgery Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Frigerio I; Hepato-Pancreato-Biliary Unit, Pederzoli Hospital, Peschiera del Garda, Italy.
  • Girelli R; Hepato-Pancreato-Biliary Unit, Pederzoli Hospital, Peschiera del Garda, Italy.
  • Delhaye M; Department of Gastroenterology, Hepatopancreatology and GI Oncology, Erasme University Hospital, Université Libre de Bruxelles, Brussels, Belgium.
  • Bernier B; Department of Gastroenterology, Hepatopancreatology and GI Oncology, Erasme University Hospital, Université Libre de Bruxelles, Brussels, Belgium.
  • Wang H; Institute of Hepatopancreatobiliary Surgery, Southwest Hospital, Third Military Medical University, Chongqing, China.
  • Jang KT; Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • Song DH; Department of Pathology, Gyeongsang National University School of Medicine, Jinju, Korea.
  • Huggett MT; Hepato-Pancreato-Biliary Unit, Freeman Hospital, Newcastle upon Tyne, UK.
  • Oppong KW; Hepato-Pancreato-Biliary Unit, Freeman Hospital, Newcastle upon Tyne, UK.
  • Pererva L; National Institute of Surgery and Transplantology named after Shalimov, Kiev, Ukraine.
  • Kopchak KV; National Institute of Surgery and Transplantology named after Shalimov, Kiev, Ukraine.
  • Del Chiaro M; Division of Surgery, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet at Center for Digestive Diseases, Karolinska University Hospital, Stockholm, Sweden.
Gut ; 65(2): 305-12, 2016 Feb.
Article en En | MEDLINE | ID: mdl-26045140
OBJECTIVES: Serous cystic neoplasm (SCN) is a cystic neoplasm of the pancreas whose natural history is poorly known. The purpose of the study was to attempt to describe the natural history of SCN, including the specific mortality. DESIGN: Retrospective multinational study including SCN diagnosed between 1990 and 2014. RESULTS: 2622 patients were included. Seventy-four per cent were women, and median age at diagnosis was 58 years (16-99). Patients presented with non-specific abdominal pain (27%), pancreaticobiliary symptoms (9%), diabetes mellitus (5%), other symptoms (4%) and/or were asymptomatic (61%). Fifty-two per cent of patients were operated on during the first year after diagnosis (median size: 40 mm (2-200)), 9% had resection beyond 1 year of follow-up (3 years (1-20), size at diagnosis: 25 mm (4-140)) and 39% had no surgery (3.6 years (1-23), 25.5 mm (1-200)). Surgical indications were (not exclusive) uncertain diagnosis (60%), symptoms (23%), size increase (12%), large size (6%) and adjacent organ compression (5%). In patients followed beyond 1 year (n=1271), size increased in 37% (growth rate: 4 mm/year), was stable in 57% and decreased in 6%. Three serous cystadenocarcinomas were recorded. Postoperative mortality was 0.6% (n=10), and SCN's related mortality was 0.1% (n=1). CONCLUSIONS: After a 3-year follow-up, clinical relevant symptoms occurred in a very small proportion of patients and size slowly increased in less than half. Surgical treatment should be proposed only for diagnosis remaining uncertain after complete workup, significant and related symptoms or exceptionally when exists concern with malignancy. This study supports an initial conservative management in the majority of patients with SCN. TRIAL REGISTRATION NUMBER: IRB 00006477.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Cistadenoma Seroso Tipo de estudio: Diagnostic_studies / Observational_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Gut Año: 2016 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Cistadenoma Seroso Tipo de estudio: Diagnostic_studies / Observational_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Gut Año: 2016 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido