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PPARδ preserves a high resistance to fatigue in the mouse medial gastrocnemius after spinal cord transection.
Kim, Jung A; Roy, Roland R; Zhong, Hui; Alaynick, William A; Embler, Emi; Jang, Claire; Gomez, Gabriel; Sonoda, Takuma; Evans, Ronald M; Edgerton, V Reggie.
Afiliación
  • Kim JA; Department of Integrative Biology and Physiology, University of California, Los Angeles, 610 Charles E. Young Drive East, Los Angeles, California, 90095-7239, USA.
  • Roy RR; Department of Integrative Biology and Physiology, University of California, Los Angeles, 610 Charles E. Young Drive East, Los Angeles, California, 90095-7239, USA.
  • Zhong H; Department of Neurosurgery, University of California, Los Angeles, Los Angeles, California, USA.
  • Alaynick WA; Department of Integrative Biology and Physiology, University of California, Los Angeles, 610 Charles E. Young Drive East, Los Angeles, California, 90095-7239, USA.
  • Embler E; Gene Expression Laboratory, Salk Institute, La Jolla, California, USA.
  • Jang C; Gene Expression Laboratory, Salk Institute, La Jolla, California, USA.
  • Gomez G; Department of Integrative Biology and Physiology, University of California, Los Angeles, 610 Charles E. Young Drive East, Los Angeles, California, 90095-7239, USA.
  • Sonoda T; Department of Integrative Biology and Physiology, University of California, Los Angeles, 610 Charles E. Young Drive East, Los Angeles, California, 90095-7239, USA.
  • Evans RM; Department of Integrative Biology and Physiology, University of California, Los Angeles, 610 Charles E. Young Drive East, Los Angeles, California, 90095-7239, USA.
  • Edgerton VR; Gene Expression Laboratory, Salk Institute, La Jolla, California, USA.
Muscle Nerve ; 53(2): 287-96, 2016 Feb.
Article en En | MEDLINE | ID: mdl-26044200
INTRODUCTION: Skeletal muscle oxidative capacity decreases and fatigability increases after spinal cord injury. Transcription factor peroxisome proliferator-activated receptor δ (PPARδ) promotes a more oxidative phenotype. METHODS: We asked whether PPARδ overexpression could ameliorate these deficits in the medial gastrocnemius of spinal cord transected (ST) adult mice. RESULTS: Time-to-peak tension and half-relaxation times were longer in PPARδ-Con and PPARδ-ST compared with littermate wild-type (WT) controls. Fatigue index was 50% higher in PPARδ-Con than WT-Con and 70% higher in the PPARδ-ST than WT-ST. There was an overall higher percent of darkly stained fibers for succinate dehydrogenase in both PPARδ groups. CONCLUSIONS: The results indicate a conversion toward slower, more oxidative, and less fatigable muscle properties with overexpression of PPARδ. Importantly, the elevated fatigue resistance was maintained after ST, suggesting that enhanced PPARδ expression, and possibly small molecule agonists, could ameliorate the increased fatigability routinely observed in chronically paralyzed muscles.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Traumatismos de la Médula Espinal / Músculo Esquelético / PPAR alfa Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Muscle Nerve Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Traumatismos de la Médula Espinal / Músculo Esquelético / PPAR alfa Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Muscle Nerve Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos