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Different dynamic resting state fMRI patterns are linked to different frequencies of neural activity.
Thompson, Garth John; Pan, Wen-Ju; Keilholz, Shella Dawn.
Afiliación
  • Thompson GJ; Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia.
  • Pan WJ; Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia.
  • Keilholz SD; Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia shella.keilholz@bme.gatech.edu.
J Neurophysiol ; 114(1): 114-24, 2015 Jul.
Article en En | MEDLINE | ID: mdl-26041826
Resting state functional magnetic resonance imaging (rsfMRI) results have indicated that network mapping can contribute to understanding behavior and disease, but it has been difficult to translate the maps created with rsfMRI to neuroelectrical states in the brain. Recently, dynamic analyses have revealed multiple patterns in the rsfMRI signal that are strongly associated with particular bands of neural activity. To further investigate these findings, simultaneously recorded invasive electrophysiology and rsfMRI from rats were used to examine two types of electrical activity (directly measured low-frequency/infraslow activity and band-limited power of higher frequencies) and two types of dynamic rsfMRI (quasi-periodic patterns or QPP, and sliding window correlation or SWC). The relationship between neural activity and dynamic rsfMRI was tested under three anesthetic states in rats: dexmedetomidine and high and low doses of isoflurane. Under dexmedetomidine, the lightest anesthetic, infraslow electrophysiology correlated with QPP but not SWC, whereas band-limited power in higher frequencies correlated with SWC but not QPP. Results were similar under isoflurane; however, the QPP was also correlated to band-limited power, possibly due to the burst-suppression state induced by the anesthetic agent. The results provide additional support for the hypothesis that the two types of dynamic rsfMRI are linked to different frequencies of neural activity, but isoflurane anesthesia may make this relationship more complicated. Understanding which neural frequency bands appear as particular dynamic patterns in rsfMRI may ultimately help isolate components of the rsfMRI signal that are of interest to disorders such as schizophrenia and attention deficit disorder.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Imagen por Resonancia Magnética Límite: Animals Idioma: En Revista: J Neurophysiol Año: 2015 Tipo del documento: Article País de afiliación: Georgia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Imagen por Resonancia Magnética Límite: Animals Idioma: En Revista: J Neurophysiol Año: 2015 Tipo del documento: Article País de afiliación: Georgia Pais de publicación: Estados Unidos