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Umbilical cord blood graft engineering: challenges and opportunities.
Thompson, P A; Rezvani, K; Hosing, C M; Oran, B; Olson, A L; Popat, U R; Alousi, A M; Shah, N D; Parmar, S; Bollard, C; Hanley, P; Kebriaei, P; Cooper, L; Kellner, J; McNiece, I K; Shpall, E J.
Afiliación
  • Thompson PA; Department of Stem Cell Transplantation and Cellular Therapy, UT MD Anderson Cancer Center, Houston, TX, USA.
  • Rezvani K; Department of Stem Cell Transplantation and Cellular Therapy, UT MD Anderson Cancer Center, Houston, TX, USA.
  • Hosing CM; Department of Stem Cell Transplantation and Cellular Therapy, UT MD Anderson Cancer Center, Houston, TX, USA.
  • Oran B; Department of Stem Cell Transplantation and Cellular Therapy, UT MD Anderson Cancer Center, Houston, TX, USA.
  • Olson AL; Department of Stem Cell Transplantation and Cellular Therapy, UT MD Anderson Cancer Center, Houston, TX, USA.
  • Popat UR; Department of Stem Cell Transplantation and Cellular Therapy, UT MD Anderson Cancer Center, Houston, TX, USA.
  • Alousi AM; Department of Stem Cell Transplantation and Cellular Therapy, UT MD Anderson Cancer Center, Houston, TX, USA.
  • Shah ND; Department of Stem Cell Transplantation and Cellular Therapy, UT MD Anderson Cancer Center, Houston, TX, USA.
  • Parmar S; Department of Stem Cell Transplantation and Cellular Therapy, UT MD Anderson Cancer Center, Houston, TX, USA.
  • Bollard C; Center for Cell Therapy and Department of Immunology, Baylor College of Medicine, Houston, TX, USA.
  • Hanley P; Center for Cell Therapy and Department of Immunology, Baylor College of Medicine, Houston, TX, USA.
  • Kebriaei P; Department of Stem Cell Transplantation and Cellular Therapy, UT MD Anderson Cancer Center, Houston, TX, USA.
  • Cooper L; Department of Stem Cell Transplantation and Cellular Therapy, UT MD Anderson Cancer Center, Houston, TX, USA.
  • Kellner J; Department of Stem Cell Transplantation and Cellular Therapy, UT MD Anderson Cancer Center, Houston, TX, USA.
  • McNiece IK; Department of Stem Cell Transplantation and Cellular Therapy, UT MD Anderson Cancer Center, Houston, TX, USA.
  • Shpall EJ; Department of Stem Cell Transplantation and Cellular Therapy, UT MD Anderson Cancer Center, Houston, TX, USA.
Bone Marrow Transplant ; 50 Suppl 2: S55-62, 2015 Jun.
Article en En | MEDLINE | ID: mdl-26039209
We are entering a very exciting era in umbilical cord blood transplantation (UCBT), where many of the associated formidable challenges may become treatable by ex vivo graft manipulation and/or adoptive immunotherapy utilizing specific cellular products. We envisage the use of double UCBT rather than single UCBT for most patients; this allows for greater ability to treat larger patients as well as to manipulate the graft. Ex vivo expansion and/or fucosylation of one cord will achieve more rapid engraftment, minimize the period of neutropenia and also give certainty that the other cord will provide long-term engraftment/immune reconstitution. The non-expanded (and future dominant) cord could be chosen for characteristics such as better HLA matching to minimize GvHD, or larger cell counts to enable part of the unit to be utilized for the development of specific cellular therapies such as the production of virus-specific T-cells or chimeric-antigen receptor T-cells which are reviewed in this study.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Refuerzo Inmunológico de Injertos / Ingeniería de Tejidos / Trasplante de Células Madre de Sangre del Cordón Umbilical / Supervivencia de Injerto / Enfermedad Injerto contra Huésped Límite: Humans Idioma: En Revista: Bone Marrow Transplant Asunto de la revista: TRANSPLANTE Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Refuerzo Inmunológico de Injertos / Ingeniería de Tejidos / Trasplante de Células Madre de Sangre del Cordón Umbilical / Supervivencia de Injerto / Enfermedad Injerto contra Huésped Límite: Humans Idioma: En Revista: Bone Marrow Transplant Asunto de la revista: TRANSPLANTE Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido