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Challenges in the management of disseminated progressive histoplasmosis in human immunodeficiency virus-infected patients in resource-limited settings.
Murphy, Richard A; Gounder, Lilishia; Manzini, Thandekile C; Ramdial, Pratistadevi K; Castilla, Carmen; Moosa, Mahomed-Yunus S.
Afiliación
  • Murphy RA; Médecins Sans Frontières/Doctors Without Borders ; Albert Einstein College of Medicine , Bronx, New York, New York.
  • Gounder L; Department of Infectious Diseases , Nelson R. Mandela School of Medicine.
  • Manzini TC; Department of Infectious Diseases , Nelson R. Mandela School of Medicine.
  • Ramdial PK; Department of Anatomical Pathology , University of KwaZulu-Natal , Durban , South Africa.
  • Castilla C; New York University School of Medicine.
  • Moosa MY; Department of Infectious Diseases , Nelson R. Mandela School of Medicine.
Open Forum Infect Dis ; 2(1): ofv025, 2015 Jan.
Article en En | MEDLINE | ID: mdl-26034774
The diagnosis of histoplasmosis in patients with human immunodeficiency virus in southern Africa is complicated by the nonspecific presentation of the disease in this patient group and the unavailability of sensitive diagnostics including antigen assays. Treatment options are also limited due to the unavailability of liposomal amphotericin and itraconazole, and the inability to perform therapeutic drug monitoring further confounds management. We present 3 clinical cases to illustrate the limits of diagnosis and management in the southern African context, and we highlight the need for additional diagnostic tools and treatment options in resource-limited settings.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Open Forum Infect Dis Año: 2015 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Open Forum Infect Dis Año: 2015 Tipo del documento: Article Pais de publicación: Estados Unidos