Iatrogenic Cushing's syndrome in children presenting at Children's Hospital Lahore using nappy rash ointments.
J Pak Med Assoc
; 65(5): 463-6, 2015 May.
Article
en En
| MEDLINE
| ID: mdl-26028377
OBJECTIVE: To study the characteristics of infants and children presenting with iatrogenic Cushing's Syndrome due to nappy rash ointments. METHODS: The descriptive study was conducted at the Children's Hospital, Lahore, from April to September 2013, and comprised patients presenting with cushingoid features and history of using nappy rash ointments. Patients having Cushing's Syndrome due to causes other than iatrogenic were excluded and so were those taking oral or parenteral steroids due to skin allergy, renal or respiratory disease. Demographic data, history and examination of all patients were recorded on a proforma and results were analysed using SPSS 16. RESULTS: Of the total 18 patients, 13(72%) were girls and 5(27%) were boys. Eight (44.4%) patients were younger than 6 months, 6(33.3%) were between 6 months to 1 year, while 4(22.2%) were between 12 and 18 months of age. Clobetasol alone was the most frequently used agent responsible in 13(72%) cases. Duration of use of steroid ointment was as short as 3 weeks to as much as 1 year. All the patients were using disposable diapers. Ointment was prescribed by a doctor in 5(27%) cases and self-prescribed (relative or neighbour) in 13(72%). CONCLUSIONS: Self-medication and prolonged use of potent steroid ointments are major contributors in development of iatrogenic Cushing's Syndrome in infants and children. Younger age, female gender and use of disposable diapers were other important predisposing factors.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Clobetasol
/
Síndrome de Cushing
/
Dermatitis del Pañal
/
Glucocorticoides
Tipo de estudio:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Female
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Humans
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Infant
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Male
País/Región como asunto:
Asia
Idioma:
En
Revista:
J Pak Med Assoc
Año:
2015
Tipo del documento:
Article
País de afiliación:
Pakistán
Pais de publicación:
Pakistán