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Intra-nodal injection of gentamicin for the treatment of suppurated cat scratch disease's lymphadenitis.
Garnier, Camille; Martin-Blondel, Guillaume; Debuisson, Cécile; Dubois, Damien; Debard, Alexa; Cuzin, Lise; Massip, Patrice; Delobel, Pierre; Marchou, Bruno.
Afiliación
  • Garnier C; Department of Infectious and Tropical Diseases, Toulouse University Hospital, Place du Docteur Baylac TSA 40031, 31059, Toulouse Cedex 9, France. garnier.cml@gmail.com.
  • Martin-Blondel G; Department of Infectious and Tropical Diseases, Toulouse University Hospital, Place du Docteur Baylac TSA 40031, 31059, Toulouse Cedex 9, France. martin-blondel.g@chu-toulouse.fr.
  • Debuisson C; INSERM U1043-CNRS UMR 5282, Centre de Physiopathologie Toulouse-Purpan, Toulouse, France. martin-blondel.g@chu-toulouse.fr.
  • Dubois D; Université Toulouse III, 31000, Toulouse, France. martin-blondel.g@chu-toulouse.fr.
  • Debard A; Department of Paediatrics, Toulouse University Hospital, Toulouse, France.
  • Cuzin L; INSERM U1043-CNRS UMR 5282, Centre de Physiopathologie Toulouse-Purpan, Toulouse, France.
  • Massip P; Department of Bacteriology, Toulouse University Hospital, Toulouse, France.
  • Delobel P; Department of Infectious and Tropical Diseases, Toulouse University Hospital, Place du Docteur Baylac TSA 40031, 31059, Toulouse Cedex 9, France.
  • Marchou B; Department of Infectious and Tropical Diseases, Toulouse University Hospital, Place du Docteur Baylac TSA 40031, 31059, Toulouse Cedex 9, France.
Infection ; 44(1): 23-7, 2016 Feb.
Article en En | MEDLINE | ID: mdl-26001741
PURPOSE: Cat scratch disease (CSD)'s lymphadenitis may have a protracted course with painful suppuration necessitating several needle aspirations or surgical drainage. The objective of this study was to evaluate the benefit of an intra-nodal injection of gentamicin add-on oral azithromycin treatment on the outcome of suppurated CSD's lymphadenitis. METHODS: We performed a retrospective monocentric study including 51 consecutive patients diagnosed between Jan 2009 and Mar 2014 with suppurated CSD who had a positive PCR for Bartonella henselae DNA in pus collected from lymph node by needle aspiration, and who were treated with azithromycin. RESULTS: Among them, 26/51 patients (51%) received oral azithromycin only, of whom 8 patients (31%) were cured and 18 patients (69%) had complications, while 25/51 patients (49%) received an intra-nodal injection of gentamicin add-on oral azithromycin, of whom 16 patients (64 %) were cured and 9 patients (36%) had complications. In univariate analysis, the combined treatment was the only variable related to cure without complications (64 versus 31%, p = 0.01), but this difference did not remain statistically significant in multivariate analysis (OR = 3.84, 95% CI: 0.95-15.56, p = 0.06). CONCLUSIONS: Intra-nodal injection of gentamicin add-on oral azithromycin treatment might improve the outcome of patients with suppurated CSD's lymphadenitis, deserving further randomized studies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Gentamicinas / Enfermedad por Rasguño de Gato / Inyecciones / Linfadenitis / Antibacterianos Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adolescent / Adult / Animals / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged Idioma: En Revista: Infection Año: 2016 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Gentamicinas / Enfermedad por Rasguño de Gato / Inyecciones / Linfadenitis / Antibacterianos Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adolescent / Adult / Animals / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged Idioma: En Revista: Infection Año: 2016 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Alemania