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Impact of bariatric surgery on carotid artery inflammation and the metabolic activity in different adipose tissues.
Bucerius, Jan; Vijgen, Guy H E J; Brans, Boudewijn; Bouvy, Nicole D; Bauwens, Matthias; Rudd, James H F; Havekes, Bas; Fayad, Zahi A; van Marken Lichtenbelt, Wouter D; Mottaghy, Felix M.
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  • Bucerius J; From the Department of Nuclear Medicine (JB, BB, MB, FMM); Cardiovascular Research Institute Maastricht (CARIM) (JB), Maastricht University Medical Center, Maastricht, The Netherlands; Department of Nuclear Medicine (JB, FMM), University Hospital, RWTH Aachen, Aachen, Germany; Department of Human Biology (GHEJV, MB, BH, WDVML), School for Nutrition, Toxicology, and Metabolism (NUTRIM); Department of General Surgery (GHEJV, NDB), Maastricht University Medical Center, Maastricht, The Netherlands;
Medicine (Baltimore) ; 94(20): e725, 2015 May.
Article en En | MEDLINE | ID: mdl-25997038
In this study, we unravel a molecular imaging marker correlated with the known reduction of cardiovascular events (most commonly related to vulnerable plaques) in morbidly obese patients after bariatric surgery (BaS).We prospectively imaged 10 morbidly obese subjects with F-fluorodeoxyglucose (F-FDG) positron emission tomography/computed tomography before and 1 year after BaS. F-FDG uptake-which is enhanced in inflamed, atherosclerotic vessels and in metabolically active adipose tissues-was quantified in the carotids, pericardial adipose tissue (PAT), visceral adipose tissue (VAT), as well as brown adipose tissue (BAT). The degree of carotid inflammation was compared to lean and overweight controls.Carotid inflammation significantly declined leading to an F-FDG uptake comparable to the 2 control groups. Metabolic activity significantly decreased in PAT and VAT and increased in BAT.BaS leads to a normalization of carotid artery inflammation and a beneficial impact on the metabolic activity in PAT, VAT, and BAT that is related to the metabolic syndrome observed in this patient group.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Arteritis / Obesidad Mórbida / Enfermedades de las Arterias Carótidas / Tejido Adiposo / Cirugía Bariátrica Límite: Adult / Female / Humans / Male Idioma: En Revista: Medicine (Baltimore) Año: 2015 Tipo del documento: Article Pais de publicación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Arteritis / Obesidad Mórbida / Enfermedades de las Arterias Carótidas / Tejido Adiposo / Cirugía Bariátrica Límite: Adult / Female / Humans / Male Idioma: En Revista: Medicine (Baltimore) Año: 2015 Tipo del documento: Article Pais de publicación: Estados Unidos