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A eudesmane-type sesquiterpene isolated from Pluchea odorata (L.) Cass. combats three hallmarks of cancer cells: Unrestricted proliferation, escape from apoptosis and early metastatic outgrowth in vitro.
Blaschke, Michael; McKinnon, Ruxandra; Nguyen, Chi Huu; Holzner, Silvio; Zehl, Martin; Atanasov, Atanas Georgiev; Schelch, Karin; Krieger, Sigurd; Diaz, Rene; Frisch, Richard; Feistel, Björn; Jäger, Walter; Ecker, Gerhard F; Dirsch, Verena M; Grusch, Michael; Zupko, Istvan; Urban, Ernst; Kopp, Brigitte; Krupitza, Georg.
Afiliación
  • Blaschke M; Department of Pharmacognosy, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria; Department of Clinical Pathology, Medical University of Vienna, Waehringer Guertel 18-20, Austria.
  • McKinnon R; Department of Pharmacognosy, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria.
  • Nguyen CH; Department of Clinical Pathology, Medical University of Vienna, Waehringer Guertel 18-20, Austria; Department of Clinical Pharmacy and Diagnostics, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria.
  • Holzner S; Department of Clinical Pathology, Medical University of Vienna, Waehringer Guertel 18-20, Austria.
  • Zehl M; Department of Pharmacognosy, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria; Department of Pharmaceutical Chemistry, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria.
  • Atanasov AG; Department of Pharmacognosy, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria.
  • Schelch K; Department of Medicine I, Institute of Cancer Research, Comprehensive Cancer Centre Vienna, Medical University of Vienna, Borschkegasse 8a, A-1090 Vienna, Austria.
  • Krieger S; Department of Clinical Pathology, Medical University of Vienna, Waehringer Guertel 18-20, Austria.
  • Diaz R; Institute for Ethnobiology, Playa Diana, San José/Petén, Guatemala.
  • Frisch R; Institute for Ethnobiology, Playa Diana, San José/Petén, Guatemala.
  • Feistel B; Finzelberg GmbH & Co. KG, Koblenzer Strasse 48-54, D-56626 Andernach, Germany.
  • Jäger W; Department of Clinical Pharmacy and Diagnostics, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria.
  • Ecker GF; Department of Pharmaceutical Chemistry, Division of Drug Design and Medicinal Chemistry, University of Vienna, Althanstraße 14, A-1090 Vienna, Austria.
  • Dirsch VM; Department of Pharmacognosy, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria.
  • Grusch M; Department of Medicine I, Institute of Cancer Research, Comprehensive Cancer Centre Vienna, Medical University of Vienna, Borschkegasse 8a, A-1090 Vienna, Austria.
  • Zupko I; Department of Pharmacodynamics and Biopharmacy, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary.
  • Urban E; Department of Pharmaceutical Chemistry, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria.
  • Kopp B; Department of Pharmacognosy, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria.
  • Krupitza G; Department of Clinical Pathology, Medical University of Vienna, Waehringer Guertel 18-20, Austria. Electronic address: georg.krupitza@meduniwien.ac.at.
Mutat Res ; 777: 79-90, 2015 Jul.
Article en En | MEDLINE | ID: mdl-25989051
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Extractos Vegetales / Apoptosis / Asteraceae / Sesquiterpenos de Eudesmano / Proliferación Celular Límite: Animals / Humans / Male Idioma: En Revista: Mutat Res Año: 2015 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Extractos Vegetales / Apoptosis / Asteraceae / Sesquiterpenos de Eudesmano / Proliferación Celular Límite: Animals / Humans / Male Idioma: En Revista: Mutat Res Año: 2015 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Países Bajos