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Anti-Restenotic Roles of Dihydroaustrasulfone Alcohol Involved in Inhibiting PDGF-BB-Stimulated Proliferation and Migration of Vascular Smooth Muscle Cells.
Li, Pei-Chuan; Sheu, Ming-Jyh; Ma, Wei-Fen; Pan, Chun-Hsu; Sheu, Jyh-Horng; Wu, Chieh-Hsi.
Afiliación
  • Li PC; Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA. lipeichu@usc.edu.
  • Sheu MJ; School of Pharmacy, China Medical University, Taichung 404, Taiwan. lipeichu@usc.edu.
  • Ma WF; School of Pharmacy, China Medical University, Taichung 404, Taiwan. soybean13mtdtw@gmail.com.
  • Pan CH; School of Nursing, China Medical University, Taichung 404, Taiwan. lhdaisy@mail.cmu.edu.tw.
  • Sheu JH; Department of Pharmacy, Taipei Medical University, Taipei 110, Taiwan. panch@tmu.edu.tw.
  • Wu CH; Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan. sheu@mail.nsysu.edu.tw.
Mar Drugs ; 13(5): 3046-60, 2015 May 15.
Article en En | MEDLINE | ID: mdl-25988521
Dihydroaustrasulfone alcohol (DA), an active compound firstly isolated from marine corals, has been reported to reveal anti-cancer and anti-inflammation activities. These reported activities of DA raised a possible application in anti-restenosis. Abnormal proliferation and migration of vascular smooth muscle cells (VSMCs) and the stimulation of platelet-derived growth factor (PDGF)-BB play major pathological processes involved in the development of restenosis. Experimental results showed that DA markedly reduced balloon injury-induced neointima formation in the rat carotid artery model and significantly inhibited PDGF-BB-stimulated proliferation and migration of VSMCs. Our data further demonstrated that translational and active levels of several critical signaling cascades involved in VSMC proliferation, such as extracellular signal-regulated kinase/ mitogen-activated protein kinases (ERK/MAPK), phosphatidylinositol 3-kinase (PI3K)/AKT, and signal transducer and activator of transcription (STAT), were obviously inhibited. In addition, DA also decreased the activation and expression levels of gelatinases (matrix metalloproteinase (MMP)-2 and MMP-9) involved in cell migration. In conclusion, our findings indicate that DA can reduce balloon injury-neointimal hyperplasia, the effect of which may be modulated through suppression of VSMC proliferation and migration. These results suggest that DA has potential application as an anti-restenotic agent for the prevention of restenosis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sulfonas / Butanonas / Movimiento Celular / Proteínas Proto-Oncogénicas c-sis / Reestenosis Coronaria / Miocitos del Músculo Liso / Proliferación Celular / Músculo Liso Vascular Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Mar Drugs Asunto de la revista: BIOLOGIA / FARMACOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sulfonas / Butanonas / Movimiento Celular / Proteínas Proto-Oncogénicas c-sis / Reestenosis Coronaria / Miocitos del Músculo Liso / Proliferación Celular / Músculo Liso Vascular Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Mar Drugs Asunto de la revista: BIOLOGIA / FARMACOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza