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Utility of a Paediatric Bleeding Questionnaire as a screening tool for von Willebrand disease in apparently healthy children.
Mittal, N; Naridze, R; James, P; Shott, S; Valentino, L A.
Afiliación
  • Mittal N; Department of Pediatric Hematology Oncology, Rush University Medical Center, Chicago, IL, USA.
  • Naridze R; Department of Pediatric Hematology Oncology, Rush University Medical Center, Chicago, IL, USA.
  • James P; Department of Medicine, Queens University, Kingston, ON, Canada.
  • Shott S; Department of Medicine, Rush University Medical Center, Chicago, IL, USA.
  • Valentino LA; Department of Pediatric Hematology Oncology, Rush University Medical Center, Chicago, IL, USA.
Haemophilia ; 21(6): 806-11, 2015 Nov.
Article en En | MEDLINE | ID: mdl-25982122
UNLABELLED: von Willebrand disease (VWD), an inherited bleeding disorder caused by deficiency or dysfunction of von Willebrand factor (VWF) is diagnosed when a personal and often a family history of excessive mucocutaneous bleeding is present along with abnormal laboratory studies. An accurate assessment of haemorrhagic symptoms is key in suspecting VWD but presents a challenge especially in children due to overlap between normal and abnormal bleeding. Bleeding questionnaire (BQ) scores have been validated in adults and have recently been validated in children with VWD for assessing bleeding severity. However, there are limited data supporting their use prospectively in healthy children with bleeding complaints. AIM: The objectives of this study were to obtain normative data from children and validate a paediatric BQ (PBQ) to determine the discriminative ability of its total score and its individual components for identifying children likely to have VWD. METHODS: The PBQ was administered to 1281 multiethnic, healthy children between 30 days and 18 years of age presenting to a general paediatric office and to 35 children with VWD based on VWF antigen, activity and multimer pattern. RESULTS: When children with total BQ scores of 3 or more were predicted to have VWD, the sensitivity was 97.2%, the specificity was 97.1%, the positive predictive value was 48.6% and the negative predictive value was 99.9%. CONCLUSIONS: The PBQ may help discriminate a significant bleeding history from trivial bleeding, may be integrated into the primary care algorithm for evaluating children suspected with VWD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades de von Willebrand / Tamizaje Masivo / Encuestas y Cuestionarios / Voluntarios Sanos / Hemorragia Tipo de estudio: Diagnostic_studies / Prognostic_studies / Screening_studies Aspecto: Patient_preference Límite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Haemophilia Asunto de la revista: HEMATOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades de von Willebrand / Tamizaje Masivo / Encuestas y Cuestionarios / Voluntarios Sanos / Hemorragia Tipo de estudio: Diagnostic_studies / Prognostic_studies / Screening_studies Aspecto: Patient_preference Límite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Haemophilia Asunto de la revista: HEMATOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido