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Omega 3 (n-3) fatty acids down-regulate nuclear factor-kappa B (NF-κB) gene and blood cell adhesion molecule expression in patients with homozygous sickle cell disease.
Daak, Ahmed A; Elderdery, Abozer Y; Elbashir, Leana M; Mariniello, Katia; Mills, Jeremy; Scarlett, Garry; Elbashir, Mustafa I; Ghebremeskel, Kebreab.
Afiliación
  • Daak AA; Lipidomics and Nutrition Research Center, Faculty of Life Sciences and Computing, London Metropolitan University, London, UK; Department of Medical Biochemistry, Faculty of Medicine, University of Khartoum, Sudan; Harvard School of Public Health, Harvard University, USA. Electronic address: ahmed.ma
  • Elderdery AY; School of Pharmacy and Biomedical Sciences, Faculty of Science, University of Portsmouth, UK.
  • Elbashir LM; Department of Medical Biochemistry, Faculty of Medicine, University of Khartoum, Sudan.
  • Mariniello K; Lipidomics and Nutrition Research Center, Faculty of Life Sciences and Computing, London Metropolitan University, London, UK.
  • Mills J; School of Pharmacy and Biomedical Sciences, Faculty of Science, University of Portsmouth, UK.
  • Scarlett G; School of Pharmacy and Biomedical Sciences, Faculty of Science, University of Portsmouth, UK.
  • Elbashir MI; Department of Medical Biochemistry, Faculty of Medicine, University of Khartoum, Sudan.
  • Ghebremeskel K; Lipidomics and Nutrition Research Center, Faculty of Life Sciences and Computing, London Metropolitan University, London, UK.
Blood Cells Mol Dis ; 55(1): 48-55, 2015 Jun.
Article en En | MEDLINE | ID: mdl-25976467
Chronic inflammation and reduced blood levels of omega-3 fatty acids (n-3) are known characteristics of sickle cell disease (SCD).The anti-inflammatory properties of n-3 fatty acids are well recognized. Omega-3 treated (n = 24), hydroxyurea (HU) treated (n = 18), and n-3 untreated (n=21) homozygous SCD patients (HbSS) and healthy (HbAA) controls (n = 25) matched for age (5-16 years), gender and socioeconomic status were studied. According to age (5-10) or (11-16) years, two or three capsules containing 277.8 mg docosahexaenoic (DHA) and 39.0mg eicosapentaenoic (EPA) or high oleic acid placebo (41%) were assigned to n-3 treated and n-3 untreated groups, respectively. Hydroxyurea treated group was on dosage more than 20 mg/kg/day. The effect of supplementation on systemic and blood cell markers of inflammation was investigated. The n-3 treated group had higher levels of DHA and EPA (p < 0.001) and lower white blood cell count and monocyte integrin (p < 0.05) compared with the n-3 untreated. No difference was detected between the two groups regarding C-reactive protein, granulocytes integrin and selectin, plasma tumour necrosis factor-α and interleukin-10. The n-3 treated group had lowered nuclear factor-kappa B (NF-κB) gene expression compared to n-3 untreated and HU treated groups (p < 0.05). This study provides evidence that supplementation with n-3 fatty acids may ameliorate inflammation and blood cell adhesion in patients with SCD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácido Eicosapentaenoico / Ácidos Docosahexaenoicos / FN-kappa B / Suplementos Dietéticos / Anemia de Células Falciformes Tipo de estudio: Clinical_trials / Observational_studies Idioma: En Revista: Blood Cells Mol Dis Asunto de la revista: HEMATOLOGIA Año: 2015 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácido Eicosapentaenoico / Ácidos Docosahexaenoicos / FN-kappa B / Suplementos Dietéticos / Anemia de Células Falciformes Tipo de estudio: Clinical_trials / Observational_studies Idioma: En Revista: Blood Cells Mol Dis Asunto de la revista: HEMATOLOGIA Año: 2015 Tipo del documento: Article Pais de publicación: Estados Unidos