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Tumour-associated mast cells in classical Hodgkin's lymphoma: correlation with histological subtype, other tumour-infiltrating inflammatory cell subsets and outcome.
Andersen, Maja D; Kamper, Peter; Nielsen, Patricia S; Bendix, Knud; Riber-Hansen, Rikke; Steiniche, Torben; Hamilton-Dutoit, Stephen; Clausen, Michael; d'Amore, Francesco.
Afiliación
  • Andersen MD; Department of Hematology, Aarhus University Hospital, Aarhus, Denmark.
  • Kamper P; Department of Hematology, Aarhus University Hospital, Aarhus, Denmark.
  • Nielsen PS; Institute of Pathology, Aarhus University Hospital, Aarhus, Denmark.
  • Bendix K; Institute of Pathology, Aarhus University Hospital, Aarhus, Denmark.
  • Riber-Hansen R; Institute of Pathology, Aarhus University Hospital, Aarhus, Denmark.
  • Steiniche T; Institute of Pathology, Aarhus University Hospital, Aarhus, Denmark.
  • Hamilton-Dutoit S; Institute of Pathology, Aarhus University Hospital, Aarhus, Denmark.
  • Clausen M; Department of Hematology, Aarhus University Hospital, Aarhus, Denmark.
  • d'Amore F; Department of Hematology, Aarhus University Hospital, Aarhus, Denmark.
Eur J Haematol ; 96(3): 252-9, 2016 Mar.
Article en En | MEDLINE | ID: mdl-25963595
The tumour microenvironment in classical Hodgkin's lymphoma (cHL) is characterised by a minor population of neoplastic Hodgkin and Reed-Sternberg cells within a heterogeneous background of non-neoplastic bystanders cells, including mast cells. The number of infiltrating mast cells in cHL has been reported to correlate with poor prognosis. We used immunohistochemistry to assess the degree of tumour-infiltrating mast cells in cHL tissue microarrays and correlated this with clinico-pathological features and prognosis in a cohort of homogeneously treated patients with Hodgkin's disease. A high degree of tumour mast cells was associated with nodular sclerosis (NS) subtype histology (P = 0.0002). Moreover, the number of mast cells was inversely correlated with the numbers of CD68+ and CD163+ macrophages (P = 0.0001 and P = 0.003, respectively) and with the number of granzyme+ cytotoxic cells (P = 0.004). The degree of mast cell infiltration was not a prognostic factor in cHL of nodular sclerosis subtype. In contrast, in mixed cellularity cHL a high number of intratumoral mast cells correlated with significantly poorer outcome both in terms of overall (P = 0.03) and event-free survival (P = 0.01). Further studies are warranted into the biological mechanisms underlying this adverse outcome and their possible therapeutic implications.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Hodgkin / Mastocitos Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Eur J Haematol Asunto de la revista: HEMATOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Hodgkin / Mastocitos Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Eur J Haematol Asunto de la revista: HEMATOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Reino Unido