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Permeability test for transdermal and local therapeutic patches using Skin PAMPA method.
Vizserálek, Gábor; Berkó, Szilvia; Tóth, Gergo; Balogh, Réka; Budai-Szucs, Mária; Csányi, Erzsébet; Sinkó, Bálint; Takács-Novák, Krisztina.
Afiliación
  • Vizserálek G; Department of Pharmaceutical Chemistry, Semmelweis University, 9 Hogyes Endre Street, H-1092 Budapest, Hungary.
  • Berkó S; Department of Pharmaceutical Technology, University of Szeged, 6 Eötvös Street, H-6720 Szeged, Hungary.
  • Tóth G; Department of Pharmaceutical Chemistry, Semmelweis University, 9 Hogyes Endre Street, H-1092 Budapest, Hungary.
  • Balogh R; Department of Pharmaceutical Chemistry, Semmelweis University, 9 Hogyes Endre Street, H-1092 Budapest, Hungary.
  • Budai-Szucs M; Department of Pharmaceutical Technology, University of Szeged, 6 Eötvös Street, H-6720 Szeged, Hungary.
  • Csányi E; Department of Pharmaceutical Technology, University of Szeged, 6 Eötvös Street, H-6720 Szeged, Hungary.
  • Sinkó B; Department of Pharmaceutical Chemistry, Semmelweis University, 9 Hogyes Endre Street, H-1092 Budapest, Hungary; SinkoLAB Scientific, 23 Bécsi Street, H-9400 Sopron, Hungary.
  • Takács-Novák K; Department of Pharmaceutical Chemistry, Semmelweis University, 9 Hogyes Endre Street, H-1092 Budapest, Hungary. Electronic address: novak.krisztina@pharma.semmelweis-univ.hu.
Eur J Pharm Sci ; 76: 165-72, 2015 Aug 30.
Article en En | MEDLINE | ID: mdl-25957747
Using the skin as absorption site presents unique advantages that have facilitated the progression of transdermal drug delivery in the past decades. Efforts in drug research have been devoted to find a quick and reproducible model for predicting the skin permeation of molecules. The Parallel Artificial Membrane Permeability Assay (PAMPA) has been extended for prediction of transdermal permeation by developing a model with completely artificial membrane, which can mimic the permeation through the stratum corneum. The present study aims to extend the Skin PAMPA method for testing transdermal and local therapeutic patches. The original method was modified and seven commercially available transdermal and local therapeutic patches with four different active pharmaceutical ingredients (nicotine, fentanyl, rivastigmine and ketoprofen) were studied. Data were compared to the declared delivery rates that are indicated by the manufacturers. Ex vivo permeation study was also performed in order to compare the permeated amount of the released drugs obtained by the two methods. The flux across the artificial membrane as well as the human skin (ex vivo) has been calculated and compared to the in vivo flux deduced from the labelled delivery rate and the active area of the patches. The results suggest that Skin PAMPA system can serve as a useful tool for evaluation and classification of the transdermal patches.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piel / Absorción Cutánea / Fentanilo / Cetoprofeno / Tecnología Farmacéutica / Rivastigmina / Membranas Artificiales / Nicotina Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Eur J Pharm Sci Asunto de la revista: FARMACIA / FARMACOLOGIA / QUIMICA Año: 2015 Tipo del documento: Article País de afiliación: Hungria Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piel / Absorción Cutánea / Fentanilo / Cetoprofeno / Tecnología Farmacéutica / Rivastigmina / Membranas Artificiales / Nicotina Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Eur J Pharm Sci Asunto de la revista: FARMACIA / FARMACOLOGIA / QUIMICA Año: 2015 Tipo del documento: Article País de afiliación: Hungria Pais de publicación: Países Bajos