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Coupled reversion and stream-hyporheic exchange processes increase environmental persistence of trenbolone metabolites.
Ward, Adam S; Cwiertny, David M; Kolodziej, Edward P; Brehm, Colleen C.
Afiliación
  • Ward AS; School of Public and Environmental Affairs, Indiana University, Bloomington, Indiana 47405, USA.
  • Cwiertny DM; Department of Civil &Environmental Engineering, The University of Iowa, Iowa City, Iowa 52242, USA.
  • Kolodziej EP; 1] Interdisciplinary Arts and Sciences, University of Washington, Tacoma, Tacoma, Washington 98402, USA [2] Department of Civil &Environmental Engineering, University of Washington, Seattle, Washington 98195, USA.
  • Brehm CC; Department of Civil &Environmental Engineering, The University of Iowa, Iowa City, Iowa 52242, USA.
Nat Commun ; 6: 7067, 2015 May 08.
Article en En | MEDLINE | ID: mdl-25952754
Existing regulatory frameworks for aquatic pollutants in the United States are idealized, often lacking mechanisms to account for contaminants characterized by (1) bioactivity of both the parent and transformation products and (2) reversible transformations (that is, metastable products) driven by chemical or physical heterogeneities. Here, we modelled a newly discovered product-to-parent reversion pathway for trenbolone acetate (TBA) metabolites. We show increased exposure to the primary metabolite, 17α-trenbolone (17α-TBOH), and elevated concentrations of the still-bioactive primary photoproduct hydroxylated 17α-TBOH, produced via phototransformation and then converted back to 17α-trenbolone in perpetually dark hyporheic zones that exchange continuously with surface water photic zones. The increased persistence equates to a greater potential hazard from parent-product joint bioactivity at locations and times when reversion is a dominant trenbolone fate pathway. Our study highlights uncertainties and vulnerabilities with current paradigms in risk characterization.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Acetato de Trembolona / Contaminantes Químicos del Agua / Ríos / Ambiente Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Acetato de Trembolona / Contaminantes Químicos del Agua / Ríos / Ambiente Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido