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The kinetics of donor HLA class I-specific antibody absorption following a combined split liver and kidney transplant.
Key, Tim; Watson, Christopher J; Clatworthy, Menna R; O'Rourke, Cheryl M; Goodman, Reyna S; Taylor, Craig J; Butler, Andrew J.
Afiliación
  • Key T; Tissue Typing Laboratory.
  • Watson CJ; Department of Surgery.
  • Clatworthy MR; Division of Renal Medicine , Cambridge University Hospitals NHS Foundation Trust , Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ UK.
  • O'Rourke CM; Tissue Typing Laboratory.
  • Goodman RS; Tissue Typing Laboratory.
  • Taylor CJ; Tissue Typing Laboratory.
  • Butler AJ; Department of Surgery.
NDT Plus ; 3(6): 579-81, 2010 Dec.
Article en En | MEDLINE | ID: mdl-25949473
Hyperacute rejection of a transplanted liver is rare even when the recipient has circulating donor-specific alloantibodies (DSA). There is also evidence that a transplanted liver may provide immunological protection for other organs transplanted from the same donor. We monitored the kinetics of circulating DSA in a highly sensitized recipient of a combined split liver and kidney transplant and demonstrated a reduction in antibody titres immediately after liver perfusion. The absorption of DSA was not compromised by the smaller liver mass transplanted. DSA titres remained low at 3 months post-transplant, and the recipient did not experience antibody-mediated rejection.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: NDT Plus Año: 2010 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: NDT Plus Año: 2010 Tipo del documento: Article Pais de publicación: Reino Unido