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[Tripeptides slow down aging process in renal cell culture].
Khavinson, V Kh; Tarnovskaia, S I; Lin'kova, N S; Poliakova, V O; Durnova, A O; Nichik, T E; Kvetnoi, I M; D'iakonov, M M; Iakutseni, P P.
Adv Gerontol ; 27(4): 651-6, 2014.
Article en Ru | MEDLINE | ID: mdl-25946838
The mechanism of geroprotective effect of peptides AED and EDL was studied in ageing renal cell culture. Peptide AED and EDL increase cell proliferation, decreasing expression of marker of aging p16, p21, p53 and increasing expression of SIRT-6 in young and aged renal cell culture. The reduction of SIRT-6 synthesis in cell is one of the causes of cell senescence. On the basis of experimental data models of interaction of peptides with various sites of DNA were constructed. Both peptides form most energetically favorable complexes with d(ATATATATAT)2 sequences in minor groove of DNA. It is shown that interaction of peptides AED and EDL with DNA is the cause of gene expression, encoded marker of ageing in renal cells.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oligopéptidos / Senescencia Celular / Riñón Tipo de estudio: Prognostic_studies Límite: Animals Idioma: Ru Revista: Adv Gerontol Asunto de la revista: GERIATRIA Año: 2014 Tipo del documento: Article Pais de publicación: Rusia
Buscar en Google
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oligopéptidos / Senescencia Celular / Riñón Tipo de estudio: Prognostic_studies Límite: Animals Idioma: Ru Revista: Adv Gerontol Asunto de la revista: GERIATRIA Año: 2014 Tipo del documento: Article Pais de publicación: Rusia