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Compression-induced HIF-1 enhances thrombosis and PAI-1 expression in mouse skin.
Kaneko, Maki; Minematsu, Takeo; Yoshida, Mikako; Nishijima, Yoshimi; Noguchi, Hiroshi; Ohta, Yasunori; Nakagami, Gojiro; Mori, Taketoshi; Sanada, Hiromi.
Afiliación
  • Kaneko M; Department of Gerontological Nursing/Wound Care Management, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Minematsu T; Department of Gerontological Nursing/Wound Care Management, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Yoshida M; Department of Gerontological Nursing/Wound Care Management, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Nishijima Y; Department of Gerontological Nursing/Wound Care Management, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Noguchi H; Department of Life Support Technology (Molten), Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Ohta Y; Department of Pathology, Research Hospital, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
  • Nakagami G; Department of Gerontological Nursing/Wound Care Management, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Mori T; Department of Life Support Technology (Molten), Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Sanada H; Department of Gerontological Nursing/Wound Care Management, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Wound Repair Regen ; 23(5): 657-63, 2015 Sep.
Article en En | MEDLINE | ID: mdl-25939592
Pressure ulcers result from tissue hypoxia caused by external forces. Thrombosis due to external forces is considered important, and hypoxia inducible factor-1 (HIF-1) is a master regulator of pressure ulcer development. To date, however, their causal relationship has not been determined. This study therefore investigated the mutual relationship between thrombosis and HIF-1 activation in compressed mouse skin, based on a hypothesis that HIF-1 regulation by plasminogen activator inhibitor-1 (PAI-1) enhances thrombosis. Compression of mouse skin significantly increased the numbers of thrombi and HIF-1α-positive cells compared with control skin. A thrombosis inhibitor significantly reduced the numbers of HIF-1α-positive cells and an HIF-1 inhibitor significantly inhibited thrombosis in compressed skin tissue, suggesting a mutual relationship between thrombosis and HIF-1 activation. Compression of mouse skin also enhanced the level of Pai-1 messenger RNA expression, but this increase was significantly reduced by treatment with an HIF-1 inhibitor, whereas a thrombosis inhibitor had no effect. These results suggested the involvement of PAI-1 in HIF-1-enhanced thrombosis and that an additional factor participates in regulating Pai-1 expression in compressed skin. These findings may suggest new strategies in pressure ulcer management.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piel / Trombosis / Heridas y Lesiones / ARN Mensajero / Regulación de la Expresión Génica / Subunidad alfa del Factor 1 Inducible por Hipoxia / Serpina E2 Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Animals Idioma: En Revista: Wound Repair Regen Asunto de la revista: DERMATOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piel / Trombosis / Heridas y Lesiones / ARN Mensajero / Regulación de la Expresión Génica / Subunidad alfa del Factor 1 Inducible por Hipoxia / Serpina E2 Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Animals Idioma: En Revista: Wound Repair Regen Asunto de la revista: DERMATOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos