Frequencies of the Common MEFV Gene Mutations in Adiyaman, Southeast Anatolia, Turkey.
Balkan J Med Genet
; 17(2): 67-71, 2014 Dec.
Article
en En
| MEDLINE
| ID: mdl-25937800
Familial Mediterranean fever (FMF) is an autosomal recessive disorder characterized by fever and serosal inflammation. The reasons for the disorder are mutations in the Mediterranean fever (MEFV) gene; the most common of which are M694V, M680I, M694I and V726A. In this study, we aimed to screen these common mutations of the MEFV gene and then determine the prevalence of FMF according to these mutations in Adiyaman, Southeast Anatolia, Turkey. Seven hundred and sixty-seven healthy individuals from the region of Adiyaman participated in the study. Polymerase chain reaction-amplification refractory mutation system (PCR-ARMS) methods were used to determine the common mutations of the MEFV gene. Twenty-six (3.9%) individuals had only one mutation in the MEFV gene, 25 individuals were heterozygous and one person was homozygous for the V726A mutation (0.15%). In the present study, the V726A mutation (50.0%) was the most frequent, followed by M694V (38.5%), M680I (7.7%) and M694I (3.8%). It was seen that the carrier rate was very low and the prevalence of FMF was 0.15%, according to the common mutations of the MEFV gene in Adiyaman, Southeast Anatolia, Turkey.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Tipo de estudio:
Risk_factors_studies
Idioma:
En
Revista:
Balkan J Med Genet
Año:
2014
Tipo del documento:
Article
País de afiliación:
Turquía
Pais de publicación:
Polonia