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Insulin-like growth factor (IGF)-I, IGF binding protein-3, and prostate cancer: correlation with Gleason score.
Correa, Livia L; Neto, Leonardo Vieira; Lima, Giovanna A Balarini; Gabrich, Rafael; Miranda, Luiz Carlos D de; Gadelha, Monica R.
Afiliación
  • Correa LL; Endocrinology Service, University Hospital Clementino Fraga Filho (HUCFF), Universidade Federal do Rio de Janeiro, RJ, Brazil.
  • Neto LV; Instituto Estadual de Diabetes e Endocrinologia Luiz Capriglione (IEDE), Rio de Janeiro, RJ, Brazil.
  • Lima GA; Endocrinology Service, University Hospital Clementino Fraga Filho (HUCFF), Universidade Federal do Rio de Janeiro, RJ, Brazil.
  • Gabrich R; Endocrinology Service, Hospital Federal da Lagoa, Rio de Janeiro, RJ, Brazil.
  • Miranda LC; Endocrinology Service, University Hospital Clementino Fraga Filho (HUCFF), Universidade Federal do Rio de Janeiro, RJ, Brazil.
  • Gadelha MR; Endocrinology Service, University Hospital Antônio Pedro (HUAP), Universidade Federal Fluminense (UFF), Niterói, RJ, Brazil.
Int Braz J Urol ; 41(1): 110-5, 2015.
Article en En | MEDLINE | ID: mdl-25928516
INTRODUCTION: Non-androgenic growth factors are involved in the growth regulation of prostate cancer (PCa). OBJECTIVE: This is the first Brazilian study to correlate, in a population of patients operated for PCa, PSA, total testosterone, insulin-like growth factor-I (IGF-I) and insulin-like growth factor-binding protein-3 (IGFBP-3) with Gleason score and to compare with a control group with benign prostate hyperplasia (BPH). MATERIALS AND METHODS: This retrospective single-center study included 49 men with previously diagnosed PCa and 45 with previously diagnosed BPH. PSA, testosterone, IGF-I, IGFBP-3 were determined in both groups. RESULTS: PSA and IGFBP-3 levels were significantly higher in the PCa group as compared to the BPH group (p < 0.001 and p=0.004, respectively). There was a significant difference when we compared the PSA before surgery (p < 0.001) and at the inclusion in the study (p < 0.001) and IGFBP3 (0.016) among patients with Gleason < 7, ≥7 and BPH. In the PCa group, PSA, testosterone, IGF-I and IGFBP-3 levels were comparable between Gleason < 7 and ≥7. CONCLUSIONS: Our data suggest that in localized PCa, the quantification of PSA and, not of IGF-1, may provide independent significant information in the aggressiveness. IGFBP-3 could be a biochemical marker of disease control in PCa patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hiperplasia Prostática / Neoplasias de la Próstata / Testosterona / Factor I del Crecimiento Similar a la Insulina / Adenocarcinoma / Antígeno Prostático Específico / Proteína 3 de Unión a Factor de Crecimiento Similar a la Insulina Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Aged / Humans / Male / Middle aged Idioma: En Revista: Int Braz J Urol Asunto de la revista: UROLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hiperplasia Prostática / Neoplasias de la Próstata / Testosterona / Factor I del Crecimiento Similar a la Insulina / Adenocarcinoma / Antígeno Prostático Específico / Proteína 3 de Unión a Factor de Crecimiento Similar a la Insulina Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Aged / Humans / Male / Middle aged Idioma: En Revista: Int Braz J Urol Asunto de la revista: UROLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil