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Body weight gain and risk of colorectal cancer: a systematic review and meta-analysis of observational studies.
Schlesinger, S; Lieb, W; Koch, M; Fedirko, V; Dahm, C C; Pischon, T; Nöthlings, U; Boeing, H; Aleksandrova, K.
Afiliación
  • Schlesinger S; Institute of Epidemiology, Christian-Albrechts University of Kiel, Kiel, Germany.
  • Lieb W; Institute of Epidemiology, Christian-Albrechts University of Kiel, Kiel, Germany.
  • Koch M; Institute of Epidemiology, Christian-Albrechts University of Kiel, Kiel, Germany.
  • Fedirko V; Department of Epidemiology, Rollins School of Public Health, Winship Cancer Institute, Emory University, Atlanta, GA, USA.
  • Dahm CC; Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark.
  • Pischon T; Molecular Epidemiology Group, Max Delbrueck Center for Molecular Medicine (MDC), Berlin-Buch, Germany.
  • Nöthlings U; Department of Nutrition and Food Sciences, Nutritional Epidemiology, University of Bonn, Bonn, Germany.
  • Boeing H; Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany.
  • Aleksandrova K; Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany.
Obes Rev ; 16(7): 607-19, 2015 Jul.
Article en En | MEDLINE | ID: mdl-25925734
While the relationship between body mass index as an indicator of excess body weight and the risk of colorectal cancer (CRC) is well established, the association between body weight gain in adulthood and risk of CRC remains unresolved. We quantified this association in a meta-analysis of 12 observational studies published until November 2014 with a total of 16,151 incident CRC cases. Random effect models were used to obtain summary relative risks (RR) and 95% confidence intervals (95% CIs). Between-study heterogeneity was assessed using I(2) statistics. Overall, the summary RR (95% CI) was 1.22 (1.14-1.30) for high body weight gain (midpoint: 15.2 kg) compared with stable weight (P for heterogeneity = 0.182; I(2) = 21.2%). In a dose-response analysis, each 5 kg weight gain was associated with a 4% (95% CI: 2%-5%) higher risk of CRC. The association persisted after adjustment for body weight at younger age and was present for both men and women, as well as for colon and rectal cancer. Differences by sex were detected for colon cancer (P for interaction = 0.003, with higher risk for men than women), but not for rectal cancer (P for interaction = 0.613). In conclusion, these data underscore the importance of body weight management from early adulthood onwards for the prevention of CRC development.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Aumento de Peso / Obesidad Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Obes Rev Asunto de la revista: METABOLISMO Año: 2015 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Aumento de Peso / Obesidad Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Obes Rev Asunto de la revista: METABOLISMO Año: 2015 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido