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Autobiographical deficits correlate with gray matter volume in depressed and high risk participants.
Young, Kymberly D; Bellgowan, Patrick S F; Bodurka, Jerzy; Drevets, Wayne C.
Afiliación
  • Young KD; Laureate Institute for Brain Research, Tulsa, OK, USA, kyoung@laureateinstitute.org.
  • Bellgowan PS; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
  • Bodurka J; Laureate Institute for Brain Research, Tulsa, OK, USA, University of Oklahoma, Norman, OK, USA, and.
  • Drevets WC; Laureate Institute for Brain Research, Tulsa, OK, USA, Janssen Pharmaceuticals, of Johnson & Johnson, Inc., Titusville, NJ, USA.
Soc Cogn Affect Neurosci ; 10(11): 1588-95, 2015 Nov.
Article en En | MEDLINE | ID: mdl-25925269
Autobiographical memory (AM) overgenerality is a consistent neuropsychological feature of major depressive disorder (MDD) and is present in individuals at high-familial risk (HR) of developing MDD. Structural changes have been found in brain regions implicated in AM recall in MDDs and HRs. However, the relationship between selective regional gray matter volume (GMV) differences and AM recall deficits has not been examined. We examined this relationship in 27 HR, 43 unmedicated MDD and 47 low-risk healthy control participants as they completed an AM task during functional magnetic resonance imaging. FreeSurfer was used for automated anatomical image processing and volumetric quantification. Anatomical regions of interest for GMV analysis were selected based on regions most commonly activated in controls as they recall specific AMs according to a recent meta-analysis. Pearson correlations were calculated among volumetric and AM recall data. In HRs and MDDs, left hippocampal volume correlated positively with specific (HRs r = 0.42; MDDs r = 0.60) and inversely with categorical AM recall (HRs r = -0.51; MDDs r = -0.35). In MDDs, left precuneus volume also correlated positively with specific (r = 0.49) and inversely with categorical (r = -0.35) AM recall. Our results suggest selective GMV alterations within the AM network may contribute to AM impairments observed in both HR and MDD individuals.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lóbulo Parietal / Recuerdo Mental / Trastorno Depresivo Mayor / Memoria Episódica / Sustancia Gris / Hipocampo Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Soc Cogn Affect Neurosci Año: 2015 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lóbulo Parietal / Recuerdo Mental / Trastorno Depresivo Mayor / Memoria Episódica / Sustancia Gris / Hipocampo Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Soc Cogn Affect Neurosci Año: 2015 Tipo del documento: Article Pais de publicación: Reino Unido