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Computerized Assessment of Wheezing in Children With Respiratory Syncytial Virus Bronchiolitis Before and After Hypertonic Saline Nebulization.
Faber, Tina E; Kamps, Arvid Wa; Sjoerdsma, Machtelt H; Vermeulen, Stephanie; Veeger, Nic Jgm; Bont, Louis J.
Afiliación
  • Faber TE; Department of Pediatrics tina.faber@znb.nl.
  • Kamps AW; Department of Pediatrics.
  • Sjoerdsma MH; Department of Pediatrics.
  • Vermeulen S; Department of Pediatrics.
  • Veeger NJ; Department of Clinical Epidemiology, MCL Academy, Medical Center Leeuwarden, Leeuwarden, The Netherlands.
  • Bont LJ; Department of Pediatrics, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands.
Respir Care ; 60(9): 1252-6, 2015 Sep.
Article en En | MEDLINE | ID: mdl-25922547
BACKGROUND: Studies suggest an effect of nebulized hypertonic saline solution on air-flow limitation in subjects with respiratory syncytial virus (RSV) bronchiolitis, but results are based on subjective scores of clinical severity and are not clear. In this observational study, we used a noninvasive computerized tool to quantify wheezing before and after nebulization with hypertonic saline in children admitted for RSV infection. METHODS: Twenty-seven children (≤ 24 months old) admitted to the pediatric ward of the Medical Center Leeuwarden with polymerase chain reaction-confirmed RSV bronchiolitis were included. Subjects were simultaneously assessed both clinically and by computerized acoustic monitoring before and 15 min after treatment with nebulized hypertonic saline solution. RESULTS: Clinical assessment, defined by the Respiratory Distress Assessment Instrument score, did not change after nebulization (n = 27, 5.0 vs 4.7, P = .17). Computerized acoustic monitoring showed no improvement in wheezing (n = 27, 3.4% vs 2.0%, P = .05) or inspiration/expiration ratio (0.85 vs 0.85, P = .93) after nebulization. CONCLUSIONS: Hypertonic saline nebulization does not improve air flow, as assessed by both clinical and computerized acoustic scores, in children admitted for RSV.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Auscultación / Bronquiolitis Viral / Ruidos Respiratorios / Infecciones por Virus Sincitial Respiratorio / Evaluación de Síntomas Tipo de estudio: Diagnostic_studies / Observational_studies Límite: Child, preschool / Female / Humans / Infant / Male / Newborn Idioma: En Revista: Respir Care Año: 2015 Tipo del documento: Article Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Auscultación / Bronquiolitis Viral / Ruidos Respiratorios / Infecciones por Virus Sincitial Respiratorio / Evaluación de Síntomas Tipo de estudio: Diagnostic_studies / Observational_studies Límite: Child, preschool / Female / Humans / Infant / Male / Newborn Idioma: En Revista: Respir Care Año: 2015 Tipo del documento: Article Pais de publicación: Estados Unidos