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The use of Botulinum toxin-a injection for facial wrinkles: a histological and immunohistochemical evaluation.
El-Domyati, Moetaz; Attia, Sameh K; El-Sawy, Ashraf E; Moftah, Noha H; Nasif, Ghada A; Medhat, Walid; Marwan, Belkais.
Afiliación
  • El-Domyati M; Department of Dermatology, STD's and Andrology, Al-Minya University, Al-Minya, Egypt.
  • Attia SK; Department of Dermatology, STD's and Andrology, Al-Minya University, Al-Minya, Egypt.
  • El-Sawy AE; Department of Dermatology, STD's and Andrology, Al-Minya University, Al-Minya, Egypt.
  • Moftah NH; Department of Dermatology, STD's and Andrology, Al-Minya University, Al-Minya, Egypt.
  • Nasif GA; Department of Dermatology, STD's and Andrology, Al-Minya University, Al-Minya, Egypt.
  • Medhat W; Department of Dermatology, STD's and Andrology, Al-Minya University, Al-Minya, Egypt.
  • Marwan B; Department of Dermatology, STD's and Andrology, Al-Minya University, Al-Minya, Egypt.
J Cosmet Dermatol ; 14(2): 140-4, 2015 Jun.
Article en En | MEDLINE | ID: mdl-25916463
Botulinum toxin (BTX)-A has been used for years in the reduction of facial wrinkles; however, histological and immunohistochemical changes after its use were not previously investigated. To evaluate histological and immunohistochemical changes after BTX-A injection for facial wrinkles, sixteen volunteers, with wrinkles on the upper third of the face, were subjected to single injection of BTX-A. Skin biopsy specimens were obtained from peri-orbital wrinkle site (crow's feet area) before and after 3 months of BTX-A injection. Using histological and immunohistochemical evaluation coupled with computerized morphometric analysis, measurement of epidermal thickness, wrinkle depth and width as well as quantitative evaluation of collagen types I and III and elastin was performed for skin biopsies. After BTX-A injections, there were significant increase in wrinkle width and granular layer thickness (P < 0.001), while the other histometrical measures as well as the immunohistochemical expression of collagen types I and III and elastin showed no significant difference (P > 0.05). However, collagen fibers showed better organization and orientation after BTX-A injection. The histological changes observed after BTX-A injection for facial wrinkles may help in better understanding of its mechanism of action.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piel / Envejecimiento de la Piel / Toxinas Botulínicas Tipo A / Fármacos Neuromusculares Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Cosmet Dermatol Asunto de la revista: DERMATOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piel / Envejecimiento de la Piel / Toxinas Botulínicas Tipo A / Fármacos Neuromusculares Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Cosmet Dermatol Asunto de la revista: DERMATOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Reino Unido