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The role of recent thymic emigrant-regulatory T-cell (RTE-Treg) differentiation during pregnancy.
Wagner, Miriam I; Mai, Charlotte; Schmitt, Edgar; Mahnke, Karsten; Meuer, Stefan; Eckstein, Volker; Ho, Anthony D; Schaier, Matthias; Zeier, Martin; Spratte, Julia; Fluhr, Herbert; Steinborn, Andrea.
Afiliación
  • Wagner MI; Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany.
  • Mai C; Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany.
  • Schmitt E; Institute of Immunology, University of Mainz, Mainz, Germany.
  • Mahnke K; Department of Dermatology, University of Heidelberg, Heidelberg, Germany.
  • Meuer S; Institute of Immunology, University of Heidelberg, Heidelberg, Germany.
  • Eckstein V; Department of Medicine V (Hematology), University of Heidelberg, Heidelberg, Germany.
  • Ho AD; Department of Medicine V (Hematology), University of Heidelberg, Heidelberg, Germany.
  • Schaier M; Department of Medicine I (Nephrology), University of Heidelberg, Heidelberg, Germany.
  • Zeier M; Department of Medicine I (Nephrology), University of Heidelberg, Heidelberg, Germany.
  • Spratte J; Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany.
  • Fluhr H; Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany.
  • Steinborn A; Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany.
Immunol Cell Biol ; 93(10): 858-67, 2015 Nov.
Article en En | MEDLINE | ID: mdl-25915117
During pregnancy, regulatory T cells (Tregs) have a key role in maternal immune tolerance to the semi-allogeneic fetus. Our previous results showed that the naive CD45RA(+)-Treg pool is functionally improved in pregnant women compared with non-pregnant women. Therefore, we examined the thymic output and differentiation of CD45RA(+)CD31(+) recent thymic emigrant (RTE)-Tregs during normal pregnancy and in the presence of preeclampsia. With the onset of pregnancy, the composition of the total CD4(+)CD127(low+/-)FoxP3(+)-Treg pool changed in the way that its percentage of RTE- and CD45RA(-)CD31(+)-memory Tregs decreased strongly, whereas that of the CD45RA(+)CD31(-)-mature naive (MN)-Tregs did not change and that of the CD45RA(-)CD31(-)-memory Tregs increased complementary. Thereby, the ratio of RTE-/MN-Tregs decreased from 1.0 to 0.7 leading to a significant increase in the suppressive activity of the naive CD45RA(+)-Treg pool. This effect was confirmed by re-assembling separated RTE- and MN-Tregs from non-pregnant women in the ratio of pregnant women. The suppressive activity of both separated naive Treg subsets was equally high in non-pregnant and pregnant women, but considerably reduced in preeclampsia patients, who showed significantly increased percentages of CD45RA(-)CD31(+)-memory Tregs, but decreased percentages of RTE- and MN-Tregs. Our results suggest a reduced thymic output of RTE-Tregs during pregnancy, which causes a decrease in the ratio of RTE-/MN-Tregs and thus an increase in the differentiation of RTE-Tregs towards CD45RA(-)CD31(-)-memory Tregs. Presumably, this differentiation of RTE-Tregs, which was impaired in preeclampsia patients, ensures the improved suppressive activity of the CD45RA(+)-naive Treg pool and thus retains the maintenance of pregnancy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Preeclampsia / Timo / Subgrupos de Linfocitos T / Linfocitos T Reguladores Límite: Adolescent / Adult / Animals / Female / Humans / Middle aged / Pregnancy Idioma: En Revista: Immunol Cell Biol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Preeclampsia / Timo / Subgrupos de Linfocitos T / Linfocitos T Reguladores Límite: Adolescent / Adult / Animals / Female / Humans / Middle aged / Pregnancy Idioma: En Revista: Immunol Cell Biol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos