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Adult neurogenesis and the future of the rejuvenating brain circuits.
Lepousez, Gabriel; Nissant, Antoine; Lledo, Pierre-Marie.
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  • Lepousez G; Institut Pasteur, Laboratory for Perception and Memory, 25 rue du Docteur Roux, 75724 Paris, France; Centre National de la Recherche Scientifique (CNRS), Unité Mixte de Recherche 3571, 25 rue du Docteur Roux, 75724 Paris, France.
  • Nissant A; Institut Pasteur, Laboratory for Perception and Memory, 25 rue du Docteur Roux, 75724 Paris, France; Centre National de la Recherche Scientifique (CNRS), Unité Mixte de Recherche 3571, 25 rue du Docteur Roux, 75724 Paris, France.
  • Lledo PM; Institut Pasteur, Laboratory for Perception and Memory, 25 rue du Docteur Roux, 75724 Paris, France; Centre National de la Recherche Scientifique (CNRS), Unité Mixte de Recherche 3571, 25 rue du Docteur Roux, 75724 Paris, France. Electronic address: pmlledo@pasteur.fr.
Neuron ; 86(2): 387-401, 2015 Apr 22.
Article en En | MEDLINE | ID: mdl-25905812
For a long time, the mammalian brain has been perceived to be a static organ. However, the discovery of adult neurogenesis in most mammalian species, including humans, monkeys, and rodents, has disrupted this view. As this continuous regeneration has an effect on established behavioral patterns, it holds promising therapeutic potential. However, before harnessing this potential regenerative power, we must understand what effects new neurons have on existing brain circuits. Ongoing research contributes to several important steps toward bridging the gap between adult-born neurons, circuits, and behavior. The study of adult neurogenesis in different neurogenic regions from a systems neuroscience perspective will pave the way to understanding how it supports adaptive behavior and why its dysfunction correlates with some human brain disorders.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Rejuvenecimiento / Encefalopatías / Emparejamiento Cromosómico / Medicina Regenerativa / Neurogénesis / Red Nerviosa / Neuronas Tipo de estudio: Prognostic_studies Límite: Adult / Humans Idioma: En Revista: Neuron Asunto de la revista: NEUROLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Rejuvenecimiento / Encefalopatías / Emparejamiento Cromosómico / Medicina Regenerativa / Neurogénesis / Red Nerviosa / Neuronas Tipo de estudio: Prognostic_studies Límite: Adult / Humans Idioma: En Revista: Neuron Asunto de la revista: NEUROLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos