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Association Between Educational Level and Risk of Cancer in HIV-infected Individuals and the Background Population: Population-based Cohort Study 1995-2011.
Legarth, Rebecca; Omland, Lars H; Dalton, Susanne O; Kronborg, Gitte; Larsen, Carsten S; Pedersen, Court; Pedersen, Gitte; Gerstoft, Jan; Obel, Niels.
Afiliación
  • Legarth R; Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet.
  • Omland LH; Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet.
  • Dalton SO; Institute of Cancer Epidemiology, Danish Cancer Society.
  • Kronborg G; Department of Infectious Diseases, Copenhagen University Hospital, Hvidovre Hospital.
  • Larsen CS; Department of Infectious Diseases, Aarhus University Hospital.
  • Pedersen C; Department of Infectious Diseases, Odense University Hospital.
  • Pedersen G; Department of Infectious Diseases, Aalborg University Hospital, Denmark.
  • Gerstoft J; Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet.
  • Obel N; Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet.
J Infect Dis ; 212(10): 1552-62, 2015 Nov 15.
Article en En | MEDLINE | ID: mdl-25904603
BACKGROUND: Human immunodeficiency virus (HIV)-infected individuals have increased risk of cancer. To our knowledge, no previous study has examined the impact of socioeconomic position on risk and prognosis of cancer in HIV infection. METHODS: Population-based cohort-study, including HIV-infected individuals diagnosed (without intravenous drug abuse or hepatitis C infection) (n = 3205), and a background population cohort matched by age, gender, and country of birth (n = 22 435) were analyzed. Educational level (low or high) and cancer events were identified in Danish national registers. Cumulative incidences, incidence rate ratios (IRRs), and survival using Kaplan-Meier methods were estimated. RESULTS: Low educational level was associated with increased risk of cancer among HIV-infected individuals compared to population controls: all (adjusted-IRRs: 1.4 [95% confidence interval {CI}, 1.1-1.7] vs 1.1 [95% CI, .9-1.2]), tobacco- and alcohol-related (2.1 [95% CI, 1.3-3.4] vs 1.3 [95% CI, 1.1-1.6]), and other (1.7 [95% CI, 1.1-2.8] vs 0.9 [95% CI, .7-1.0]). Educational level was not associated with infection-related or ill-defined cancers. One-year-survival was not associated with educational level, but HIV-infected individuals with low educational level had lower 5-year-survival following infection-related and ill-defined cancers. CONCLUSIONS: Education is associated with risk and prognosis of some cancers in HIV infection, and diverges from what is observed in the background population.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por VIH / Neoplasias Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: J Infect Dis Año: 2015 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por VIH / Neoplasias Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: J Infect Dis Año: 2015 Tipo del documento: Article Pais de publicación: Estados Unidos