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To evaluate the damage of renal function in CIAKI rats at 3T: using ASL and BOLD MRI.
Chen, Wen-Bo; Liang, Long; Zhang, Bin; Liu, Chun-Ling; Liu, Hong-Jun; Luo, Hai-Ying; Zeng, Qiong-Xin; Liang, Chang-Hong; Liu, Guan-Shu; Zhang, Shui-Xing.
Afiliación
  • Chen WB; Department of Radiology, Guangdong Academy of Medical Sciences/Guangdong General Hospital, No. 106 Zhongshan Er Road, Guangzhou, Guangdong Province 510080, China ; Department of Radiology, HuiZhou Municipal Central Hospital, No. 41 E Ling Bei Road, Huizhou, Guangdong Province 516008, China.
  • Liang L; Department of Radiology, Guangdong Academy of Medical Sciences/Guangdong General Hospital, No. 106 Zhongshan Er Road, Guangzhou, Guangdong Province 510080, China ; Southern Medical University, No. 1838 Dadao Bei Road, Guangzhou, Guangdong Province 510515, China.
  • Zhang B; Department of Radiology, Guangdong Academy of Medical Sciences/Guangdong General Hospital, No. 106 Zhongshan Er Road, Guangzhou, Guangdong Province 510080, China ; Southern Medical University, No. 1838 Dadao Bei Road, Guangzhou, Guangdong Province 510515, China.
  • Liu CL; Department of Radiology, Guangdong Academy of Medical Sciences/Guangdong General Hospital, No. 106 Zhongshan Er Road, Guangzhou, Guangdong Province 510080, China.
  • Liu HJ; Department of Radiology, Guangdong Academy of Medical Sciences/Guangdong General Hospital, No. 106 Zhongshan Er Road, Guangzhou, Guangdong Province 510080, China.
  • Luo HY; Department of Radiology, Guangdong Academy of Medical Sciences/Guangdong General Hospital, No. 106 Zhongshan Er Road, Guangzhou, Guangdong Province 510080, China.
  • Zeng QX; Department of Radiology, Guangdong Academy of Medical Sciences/Guangdong General Hospital, No. 106 Zhongshan Er Road, Guangzhou, Guangdong Province 510080, China.
  • Liang CH; Department of Radiology, Guangdong Academy of Medical Sciences/Guangdong General Hospital, No. 106 Zhongshan Er Road, Guangzhou, Guangdong Province 510080, China.
  • Liu GS; F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA ; The Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Zhang SX; Department of Radiology, Guangdong Academy of Medical Sciences/Guangdong General Hospital, No. 106 Zhongshan Er Road, Guangzhou, Guangdong Province 510080, China ; Southern Medical University, No. 1838 Dadao Bei Road, Guangzhou, Guangdong Province 510515, China.
Biomed Res Int ; 2015: 593060, 2015.
Article en En | MEDLINE | ID: mdl-25893196
PURPOSE: To investigate noninvasive arterial spin-labeling (ASL) and blood oxygen level-dependent imaging (BOLD) sequences for measuring renal hemodynamics and oxygenation in contrast induced acute kidney injury (CIAKI) rat. MATERIALS AND METHODS: Thirteen SD rats were randomly grouped into CIAKI group and control group. Both ASL and BOLD sequences were performed at 24 h preinjection and at intervals of 0.5, 12, 24, 48, 72, and 96 h postinjection to assess renal blood flow (RBF) and relative spin-spin relaxation rate (R2(*)), respectively. RESULTS: For the CIAKI group, the value of RBF in the cortex (CO) and outer medulla (OM) of the kidney was significantly decreased (P < 0.05) at 12-48 h and regressed to baseline level (P = NS) at 72-96 h. In OM, the value of R2(*) was increased at 0.5-48 h (P < 0.05) and not statistically significant (P = NS) at 72 and 96 h. CONCLUSIONS: RBF in OM and CO and oxygen level in OM were decreased postinjection of CM. ASL combining BOLD can further identify the primary cause of the decrease of renal oxygenation in CIAKI. This approach provides means for noninvasive monitoring renal function during the first 4 days of CIAKI in clinical routine work.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oxígeno / Marcadores de Spin / Imagen por Resonancia Magnética / Lesión Renal Aguda / Corteza Renal Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Revista: Biomed Res Int Año: 2015 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oxígeno / Marcadores de Spin / Imagen por Resonancia Magnética / Lesión Renal Aguda / Corteza Renal Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Revista: Biomed Res Int Año: 2015 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos